| DC10357 |
Cenerimod |
Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. |
|
| DC9765 |
CERC-501(LY-2456302,Aticaprant)
Featured
|
CERC-501(LY-2456302) is a potent, selective antagonist of the kappa opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), respectively. |
|
| DC9154 |
Cetirizine 2HCl |
Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. |
|
| DC10440 |
Namodenoson (CF-102)
Featured
|
CF-102(2-Cl-IB-MECA) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
target: A3 adenosine receptor agonist; |
|
| DC8471 |
CGS 21680 hydrochloride
Featured
|
CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM). |
|
| DC9111 |
Chlorpheniramine Maleate |
Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. |
|
| DC9062 |
Chlorprothixene |
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
|
| DC10873 |
CID16020046
Featured
|
CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM. |
|
| DC9002 |
Cimetidine |
Cimetidine is a histamine-2 (H2) receptor antagonist. |
|
| DC8801 |
Cinacalcet (AMG-073)
Featured
|
Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
|
| DC9896 |
Cinnarizine
Featured
|
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
|
| DC2062 |
Ciproxifan (FUB-359)
Featured
|
Ciproxifan is an antagonists of H3-type histamine receptors. |
|
| DC9466 |
Ciproxifan (maleate)
Featured
|
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
|
|
| DC3147 |
Clopidogrel hydrogensulfate |
Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent. |
|
| DCAPI1417 |
Clopidogrel |
Clopidogrel is an irreversible inhibitor of the P2Y12 receptor, which is responsible for initiating signal transduction via a GPCR. The signal cascade initiates platelet aggregation and thus clopidogrel has the effect of “thinning” the blood. |
|
| DCAPI1545 |
Cloprostenol sodium |
Cloprostenol Sodium is a synthetic F series prostaglandin that functions as a potent agonist towards the PGF2αR (FP receptor). It is known that Cloprostenol Sodium is less selective than other agonists such as fluprostenol, however it displays more potenc |
|
| DC7991 |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
Featured
|
Clozapine N-oxide is a major metabolite of Clozapine noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro. |
|
| DC9067 |
Clozapine |
Clozapine(HF 1854) is a 5-HT2A/2C and dopamine receptor blocker with Ki values of 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively. |
|
| DCAPI1091 |
Conivaptan hydrochloride
Featured
|
Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. |
|
| DC11048 |
Contilisant |
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM. |
|
| DC11104 |
Tildacerfont
Featured
|
corticotropin releasing factor (CRF) antagonist. |
|
| DC10528 |
CP 376395
Featured
|
CP 376395 is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). |
|
| DC9303 |
Taprenepag(CP-544326)
Featured
|
CP-544326 is a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma. |
|
| DC9317 |
CP-809101 (hydrochloride) |
CP-809101 Hcl is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. |
|
| DC10527 |
Ciforadenant (CPI-444)
Featured
|
CPI-444 is an orally administered antagonist of the adenosine A2A receptor. It is designed to block the action of adenosine that is produced by tumors. |
|
| DC9508 |
CPPHA
Featured
|
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. |
|
| DC11154 |
CR6086 |
CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
|
| DC11980 |
CX 4338 |
CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM. |
|
| DC10203 |
CXCR2-IN-1 |
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. |
|
| DC8088 |
CYM5442
Featured
|
CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. |
|
