| DC72993 |
ANA-0 |
ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity. |
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| DC72994 |
dEF3122 |
dEF3122 is a highly potent small molecule inhibitor of influenza virus replication with IC50 of 3 nM in neuraminidase activity assays, taregts NEET family of protein NAF-1. |
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| DC72995 |
ING-1466
Featured
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ING-1466 is an orally active entry inhibitor of influenza A viruses (IAVs) with EC50 of 0.18 uM against IAV H1N1 (PR8-NS1-Gluc), binds to hemagglutinin (HA) and blocks HA-mediated viral infection. |
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| DC72996 |
JJ3297 |
JJ3297 is a potent antagonist of influenza virus non-structural protein 1 (NS1), strongly restores IFN-β mRNA levels and inhibits viral replication in MDCK cells (IC50=0.8 uM). |
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| DC72997 |
NSC125044 |
NSC125044 is a small molecule inhibitor of the influenza virus protein NS1, inhibits different influenza strains cultured in MDCK-UK cells with IC50 of 7-12 uM. |
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| DC72998 |
AWE402 |
AWE402 (AWE-402) is a small molecule inhibitor targeting M. tuberculosis cytochrome bcc-aa3 of the electron transport chain (ETC), shows MIC value of 5 nM activity against Mycobacterium tuberculosis H37Rv. |
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| DC72999 |
CK-2-63
Featured
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CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM. |
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| DC73000 |
CWHM-117 |
CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays. |
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| DC73001 |
DNDI-6174 |
DNDI-6174 is a highly potent inhibitor of Leishmania cytochrome bc1 complex activity, shows broad activity against a panel of representative visceral leishmaniasis clinical isolates from various sources (EC50=10-360 nM). |
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| DC73002 |
DSM161 |
DSM161 (DSM 161) is a high potent A. baumannii DHODH (AbDHODH) inhibitor, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates. |
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| DC73003 |
DSM186 |
DSM186 (DSM 186) is a high potent A. baumannii DHODH (AbDHODH) inhibitor with IC50 of 28 nM, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates. |
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| DC73004 |
ELQ-331 |
ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM. |
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| DC73005 |
Genz-667348 |
Genz-667348 (Genz667348) is a potent, selective P. falciparum DHODH inhibitor with IC50 of 22, 14 and 42 nM for PfDHODH, PbDHODH and PvDHODH, respectively. |
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| DC73006 |
Halofuginol |
Halofuginol (MAZ1805) is a halofuginone analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=71.1 nM), is highly active against both liver and asexual blood stages of the malaria parasite (EC50=5.8 nM, P. falciparum 3D7 parasite s |
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| DC73007 |
KNX-002 |
KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins. |
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| DC73008 |
KNX-115 |
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins. |
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| DC73009 |
MBX-2366 |
MBX-2366 (ISG-21) is a potent and specific antimalarial compound with IC50 of 3 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=2 nM) to quantitatively abolish parasite-induced permeability change |
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| DC73010 |
MBX-4055 |
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes. |
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| DC73011 |
ML276 |
ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD. |
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| DC73012 |
ML304 |
ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM). |
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| DC73013 |
MMV019266 |
MMV019266 is a potent antibabesial inhibitor with IC50 of 0.278 uM and 0.909 uM for Babesia spp. (B. bovis and B. divergens), respectively. |
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| DC73014 |
MMV396797 |
MMV396797 is a small molecule inhibitor of the parasite's phosphatidylinositol kinase PfPI4KIIIB, block parasite protein secretion and export. |
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| DC73015 |
Nemacol-1 |
Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM). |
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| DC73016 |
OJT008 |
OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb. |
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| DC73017 |
OSM-S-106 |
OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM. |
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| DC73018 |
P4Q-391 |
P4Q-391 is an antimalarial agent with selective inhibition of the parasite's coenzyme Q cycle, inhibits mitochondrial cytochrome bc1 complex (Cyt bc1). |
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| DC73019 |
SCR0911 |
SCR0911 is a potent malarial cytochrome bc1 inhibitor, inhibits cell growth and ATP synthesis in both the fast- and slow-growing M. smegmatis and M. bovis bacillus Calmette-Guérin, respectively. |
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| DC73020 |
T-3767758 |
T-3767758 is a potent, proline-uncompetitive inhibitor of prolyl-tRNA synthetase (ProRS), displays good activity with EC50 of 595 nM against P. falciparum Dd2-2D4 wild-type parasites. |
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| DC73021 |
TCMDC-136879 |
TCMDC-136879 is a cyclic acyl guanidine compound with antimalarial activity. |
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| DC73022 |
TDI-8304 |
TDI-8304 is a highly selective, macrocyclic peptide inhibitor of malaria parasite Plasmodium falciparum proteasome (Pf20S) with IC50 of 0.06 uM, shows high potency against P. falciparum strain Pf 3D7 (EC50=0.009 uM). |
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