| DC22919 |
POL3026 |
A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay. |
|
| DC22918 |
POL2438 |
A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay. |
|
| DC22342 |
MK-3207 |
A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay. |
|
| DC20924 |
CPI-1205 |
A highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM. |
|
| DC20598 |
2-BFI hydrochloride |
A highly potent, selective imidazoline I2 receptor agonist with Ki of 9.8 nM, enhances supraspinal morphine analgesia in mice.. |
|
| DC23339 |
NTRC 00660 |
A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM. |
|
| DC11637 |
MPK-09 |
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator. |
|
| DC23478 |
MRS-2365 |
A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM. |
|
| DC20935 |
CV-6209 |
A highly potent, selective platelet activating factor (PAF) inhibitor with IC50 of 75 and 170 nM for aggregation inhibition of rabbit and human platelets induced by PAF. |
|
| DC23518 |
PF-470 |
A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM. |
|
| DC21658 |
SKI-2852 |
A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively. |
|
| DC20964 |
Razaxaban |
A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases. |
|
| DC20965 |
Razaxaban hydrochloride |
A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases. |
|
| DC11936 |
TAK-915 |
A highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
|
| DC23466 |
GRN-529 |
A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM. |
|
| DC11522 |
Imarikiren hydrochloride |
A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay. |
|
| DC23863 |
eCF506 |
A highly potent, selective, orally available Src family kinase inhibitor with IC50 of <0.5 nM, <0.5 nM and for Src, Yes and Fyn kinases respectively, >950-fold selectivity for Src over ABL. |
|
| DC11823 |
BMS-929075 |
A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively. |
|
| DC23972 |
MK-2894 sodium |
A highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM. |
|
| DC22972 |
S-17092 |
A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM. |
|
| DC21815 |
WAY 163909 |
A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively). |
|
| DC26071 |
BMS-814580
Featured
|
A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM. |
|
| DC26070 |
BMS 814580 phosphate |
A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM. |
|
| DC22776 |
CCG-224406 |
A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM. |
|
| DC23953 |
Orteronel |
A highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase. |
|
| DC24016 |
Ribocil-C |
A highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli. |
|
| DC24089 |
KX2-391 mesylate
Featured
|
A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor. |
|
| DC24090 |
KX2-391 dihydrochloride
Featured
|
A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor. |
|
| DC22902 |
SNC-80
Featured
|
SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment. |
|
| DC20704 |
AVN-322 free base |
A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia. |
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