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Inhibitors & Agonists

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Cat. No. Product Name Field of Application Chemical Structure
DC25092 Wortmannin Featured A potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity.
DC23322 Vacuolin-1 Featured A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
DC25048 CGP-53716 A potent protein tyrosine kinase inhibitor that shows selectivity for PDGFR in vitro and in cells.
DC22624 Asenapine A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.
DC11772 AZD-4316 A potent respiratory syncytial virus (RSV) fusion inhibitor..
DC22929 KIN-1400 A potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression.
DC11647 JNJ-2408068 Featured JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1].
DC22791 Kinase inhibitor C1 A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.
DC11830 WK-298 A potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively..
DC21417 NSC 141562 A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis.
DC5132 Tropisetron HCL A potent SR-3 antagonist
DC22530 WEHI-345 analog A potent Src inhibitor extracted from patent WO/2012003544A1..
DC20416 Imipramine Blue A potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM.
DC22933 TLR7-Agonist-31 A potent TLR7 agonist with EC50 of 59 nM..
DC22932 TLR7-Agonist-54 A potent TLR7 agonist with EC50 of 8.6 nM. .
DC22393 IW-927 A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM).
DC22618 MMAD hydrochloride A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs)..
DC11641 Cridanimod Featured A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC22607 Masitinib mesylate A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
DC23995 Lck inhibitor 2 Featured A potent tyrosine kinases inhibitor with IC50 of 13/9/3/26/2 nM for Lck/Btk/Lyn/Syk/Txk..
DC11922 BC-1382 A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.
DC22374 BMS-299897 A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM.
DC24011 (±)-BI-D A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase.
DC20541 RUNX1-IN-17 A potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays.
DC11656 AMPK-Activator-13 A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM).
DC23288 SMBA1 A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
DC23992 FAAH inhibitor 1 A potent, and selective FAAH inhibitor with IC50 of 18 nM.
DC22748 UBP 302 A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM.
DC11643 Olomoucine Featured A potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.
DC11714 PV-1019 A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.

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