DC25092 |
Wortmannin
Featured
|
A potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity. |
|
DC23322 |
Vacuolin-1
Featured
|
A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. |
|
DC25048 |
CGP-53716 |
A potent protein tyrosine kinase inhibitor that shows selectivity for PDGFR in vitro and in cells. |
|
DC22624 |
Asenapine |
A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors. |
|
DC11772 |
AZD-4316 |
A potent respiratory syncytial virus (RSV) fusion inhibitor.. |
|
DC22929 |
KIN-1400 |
A potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression. |
|
DC11647 |
JNJ-2408068
Featured
|
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1]. |
|
DC22791 |
Kinase inhibitor C1 |
A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM. |
|
DC11830 |
WK-298 |
A potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively.. |
|
DC21417 |
NSC 141562 |
A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis. |
|
DC5132 |
Tropisetron HCL |
A potent SR-3 antagonist |
|
DC22530 |
WEHI-345 analog |
A potent Src inhibitor extracted from patent WO/2012003544A1.. |
|
DC20416 |
Imipramine Blue |
A potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
|
DC22933 |
TLR7-Agonist-31 |
A potent TLR7 agonist with EC50 of 59 nM.. |
|
DC22932 |
TLR7-Agonist-54 |
A potent TLR7 agonist with EC50 of 8.6 nM. . |
|
DC22393 |
IW-927 |
A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM). |
|
DC22618 |
MMAD hydrochloride |
A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).. |
|
DC11641 |
Cridanimod
Featured
|
A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
|
DC22607 |
Masitinib mesylate |
A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays. |
|
DC23995 |
Lck inhibitor 2
Featured
|
A potent tyrosine kinases inhibitor with IC50 of 13/9/3/26/2 nM for Lck/Btk/Lyn/Syk/Txk.. |
|
DC11922 |
BC-1382 |
A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM. |
|
DC22374 |
BMS-299897 |
A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
|
DC24011 |
(±)-BI-D |
A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase. |
|
DC20541 |
RUNX1-IN-17 |
A potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays. |
|
DC11656 |
AMPK-Activator-13 |
A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM). |
|
DC23288 |
SMBA1 |
A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
|
DC23992 |
FAAH inhibitor 1 |
A potent, and selective FAAH inhibitor with IC50 of 18 nM. |
|
DC22748 |
UBP 302 |
A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM. |
|
DC11643 |
Olomoucine
Featured
|
A potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase. |
|
DC11714 |
PV-1019 |
A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |
|