| DC20475 |
Nek2 inhibitor 72 |
A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM. |
|
| DC23063 |
FAUC 1104 |
A potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment.. |
|
| DC23064 |
FAUC 1036 |
A potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.. |
|
| DC11843 |
MT-031 |
A potent, brain penetrant, dual MAO-A and AChE inhibitor that shows neuroprotective effects both in vitro and in vivo. |
|
| DC22801 |
MK2 inhibitor III |
A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM. |
|
| DC20868 |
CCG-203586 |
A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM. |
|
| DC22472 |
Naltrexone
Featured
|
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
|
| DC22615 |
Rosuvastatin |
A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM. |
|
| DC20318 |
BCML |
A potent, competitive inhibitor of quinine-activated bitter taste receptor T2R4 with IC50 of 59 nM.. |
|
| DC11767 |
IJ-5 |
A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively. |
|
| DC11624 |
WIN-18446 |
A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM. |
|
| DC20702 |
Ilepatril |
A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively. |
|
| DC23394 |
Dual BET-Kinase inhibitor 3 |
A potent, dual BET bromodomain-kinase inhibitor with IC50 of 34, 1.1 and 1.1 nM for BRD4 BD1, JAK2 and FLT-3, respectively. |
|
| DC20885 |
CGP-74514A |
A potent, dual CDC-like kinase (CLK)/CDK inhibitor with IC50 of 148, 111, 104, 382 and 573 nM for CLK1, CLK2, CLK4, CDK1 and CDK4, respectively.. |
|
| DC24059 |
PI-103 hydrochloride
Featured
|
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively. |
|
| DC11837 |
RO-5963
Featured
|
RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53. |
|
| DC21562 |
Pz-1 |
A potent, dual pan-RET/VEGFR2 kinase inhibitor with IC50s of <1 nM for all RET, RET V804M and VEGFR2. |
|
| DC20542 |
SA 16 |
A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively. |
|
| DC22545 |
TG 100572 hydrochloride |
A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC23967 |
TG 100572 |
A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC20663 |
AMG 511 |
A potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
|
| DC11976 |
SX-576 |
A potent, equipotent CXCR1 and CXCR2 antagonist with IC50 of 31 nM and 21 nM, respectively. |
|
| DC11533 |
PH-46A N-Methyl-D-Glucamine salt |
A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
| DC11532 |
PH-46A |
A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
| DC23211 |
SKF 82958
Featured
|
A potent, full dopamine D1 agonist. |
|
| DC20939 |
NCGC00379308
Featured
|
A potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation). |
|
| DC23958 |
MRK-016 |
A potent, functionally selective, CNS-penetrating and orally bioavailable inverse agonist of benzodiazepine site of GABAA α5 receptor with Ki of 0.8-1.5 nM for α1-, α2-, α3-, andα5-containing GABAA receptors. |
|
| DC11903 |
NBUMP |
A potent, highly selective 5-HT1A receptor partial agonist with Ki of 0.1 nM, displays 460- and 260-fold selectivity for 5-HT1A over the α1-adrenergic and D2 receptors, respectively.. |
|
| DC20599 |
25CN-NBOH |
A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
|
| DC20773 |
BI-853520 |
A potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays. |
|
