| DC25066 |
NVP-BDZ 824 |
A potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM.. |
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| DC11950 |
SR-2890
Featured
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A potent, highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 of 4 nM for CK1δ. |
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| DC11839 |
Org 25543 |
A potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1.. |
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| DC21484 |
PF-04802367
Featured
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PF04802367 is a potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays; shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau; modulates tau phosphorylation in vitro and in vivo. |
|
| DC20794 |
BIO-5192 |
A potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM. |
|
| DC22760 |
JJKK-048 |
A potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL. |
|
| DC20501 |
PI3Kβ and δ inhibitor 20a |
A potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM). |
|
| DC24046 |
VTP-27999 hydrochloride |
A potent, highly selective renin inhibitor with IC50 of 0.47 nM. |
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| DC22610 |
VTP-27999 2,2,2-trifluoroacetate |
A potent, highly selective renin inhibitor with IC50 of 0.47 nM. |
|
| DC22866 |
BIO-7662 |
A potent, highly selective α4β1 integrin antagonist with Kd of <10 pM. |
|
| DC21257 |
LY2780301
Featured
|
The compound you are referring to is likely a dual inhibitor of p70S6K (S6K1) and Akt, two critical kinases in the PI3K/Akt/mTOR signaling pathway. This pathway is a central regulator of cell growth, proliferation, survival, and metabolism, and its dysregulation is frequently observed in cancers, including solid tumors and non-Hodgkin's lymphoma (NHL). A dual inhibitor targeting both p70S6K and Akt would offer a powerful therapeutic strategy to block this pathway at multiple nodes, potentially overcoming resistance mechanisms and improving treatment outcomes.
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|
| DC24003 |
TC-S 7001(Azaindole 1)
Featured
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A potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively. |
|
| DC26096 |
SR-8993 |
A potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM. |
|
| DC11609 |
VU6010608 |
A potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM. |
|
| DC11725 |
BI-0252 |
A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM. |
|
| DC20316 |
Bantag-1 trifluoroacetate
Featured
|
A potent, highly selective, peptide bombesin receptor subtype-3 (BRS-3) antagonist with IC50 of 2-8 nM for human and rodent BRS-3, displays 1000-fold selectivity over hNMBR and hGRPR, increases food intake and produces an obesity phenotype in mice.. |
|
| DC11736 |
PF-956980 |
A potent, highly specific JAK3 inhibitor with IC50 of 4 nM. |
|
| DC21861 |
Z-DON |
A potent, irreversible and cell permeable inhibitor of tissue transglutaminase with IC50 of 20 nM.. |
|
| DC21216 |
L 682777 |
A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC23777 |
R 283 |
A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC21001 |
Estrone sulfamate |
A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells. |
|
| DC22880 |
MIV-6R |
A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM. |
|
| DC22383 |
Sitaxsentan |
A potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM. |
|
| DC23661 |
Evogliptin |
A potent, long acting, reversible and competitive DPP-4 inhibitor with IC50 of 0.9 nM. |
|
| DC22890 |
Frovatriptan
Featured
|
A potent, long lasting 5-HT(1B/1D) receptor agonist as a antimigraine agent.. |
|
| DC11758 |
PB 28 dihydrochloride
Featured
|
A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively. |
|
| DC11757 |
PB 28 |
A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively. |
|
| DC22812 |
CEP-11981 |
CEP-11981 is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM. |
|
| DC22851 |
IDI-6273 |
A potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH. |
|
| DC20946 |
DD-01050 |
A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity. |
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