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Org 25543

  Cat. No.:  DC11839  
Chemical Structure
495076-64-7
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 495076-64-7
Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
Synonyms: ORG25543 HCl; ORG25543; ORG-25543; ORG 25543;
SMILES: C(NCC(N(C)C)1CCCC1)(=O)C1=CC(OC)=C(OCC2=CC=CC=C2)C(OC)=C1.[H]Cl
Formula: C24H33ClN2O4
M.Wt: 448.988
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC46392 N-Arachidonylglycine N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
DC11035 GlyT1 inhibitor 46 GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.
DC11840 ALX-1393 ALX-1393 (ALX 1393, ALX1393) is a potent, specific GlyT2 inhibitor with Ki of <1 uM.
DC11839 Org 25543 A potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1..
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