| DC21631 |
MK-8242 |
A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction. |
|
| DC11959 |
PD 184161
Featured
|
A potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM. |
|
| DC11731 |
Ruzasvir |
A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.. |
|
| DC21560 |
RC-3095
Featured
|
RC-3095 is a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo. RC-3095 inhibit the growth of human glioblastomas in vitro and in vivo. RC3095 inhibits tumor growth and decrease the levels and mRNA expression of epidermal growth factor receptors in H-69 small cell lung carcinoma.R,BRS-1) antagonist. |
|
| DC23935 |
CH-5450 |
A potent, peptide-inhibitor of human chymase with Ki of 1 nM. |
|
| DC22580 |
SCH-1473759 hydrochloride |
A potent, picomolar, dual inhibitor of Aurora A and B with IC50 of 0.02 and 0.03 nM, respectively. |
|
| DC22581 |
SCH-1473759 |
A potent, picomolar, dual inhibitor of Aurora A and B with IC50 of 0.02 and 0.03 nM, respectively. |
|
| DC11794 |
GNF-351
Featured
|
GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2. |
|
| DC21334 |
MN-25 |
A potent, reasonably selective agonist of peripheral cannabinoid receptor with Ki of 11 nM for CB2, 22-fold selectivity over the psychoactive CB1 receptors (Ki=245 nM).. |
|
| DC21377 |
NESS-040C5 |
A potent, reasonably selective cannabinoid CB2 agonist with Ki of 0.4 nM, 25-fold selectivity over CB1 receptor.. |
|
| DC11717 |
PD-321852 |
A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM. |
|
| DC12016 |
NB 001 |
A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition). |
|
| DC11958 |
CCG 258001 |
A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 280 nM. |
|
| DC11957 |
CCG 224061 |
A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 66 nM. |
|
| DC24036 |
DZ-2002 |
A potent, reversible type III inhibitor of SAHH (S-adenosyl-L-homocysteine hydrolase) with Ki of 17.9 nM. |
|
| DC22606 |
Narlaprevir |
A potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM. |
|
| DC20766 |
BETd-246 |
A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity. |
|
| DC20583 |
WNK inhibitor 7 |
A potent, selectiive inhibitor of WNK1 kinase with IC50 of 95 nM, shows IC50 of 1.39 uM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility.. |
|
| DC21271 |
Volinanserin (MDL100907)
Featured
|
A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors. |
|
| DC20851 |
BW-723C86
Featured
|
A potent, selective 5-HT2B receptor agonist with pKi of 7.1, >10-fold selectivity over 5-HT2A, 5-HT2C, and other 5-HT subtypes. |
|
| DC21285 |
MK-212 |
A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A. |
|
| DC22915 |
ST-1535 |
A potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM. |
|
| DC12017 |
NKY80 |
A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively. |
|
| DC23941 |
RU-24969
Featured
|
A potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B. |
|
| DC23002 |
DAA-1097 |
A potent, selective agonist of PBR/TSPO that inhibits [3H]PK 11195 binding to crude mitochondrial preparations of rat whole brain with IC50 of 0.92 nM.. |
|
| DC22698 |
CE-326597 |
A potent, selective agonist of the human and rat CCK1 receptor with Ki of 36 nM. |
|
| DC20295 |
2-PCCA |
A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM. |
|
| DC24029 |
PF-4840154 |
A potent, selective agonist of the rat (EC50=97 nM) and human (EC50=23 nM) TRPA1 channel. |
|
| DC23831 |
TASP0382088 |
A potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases. |
|
| DC20564 |
TBBz
Featured
|
A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM. |
|
