| DC22895 |
VU0477573 |
A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
|
| DC22964 |
PQ-10
Featured
|
A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
|
| DC11660 |
PF-4181366 |
A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM. |
|
| DC23695 |
PF-05085727 |
A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
|
| DC22920 |
AMN 082 dihydrochloride |
A potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
|
| DC23640 |
ASP2535 |
A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2. |
|
| DC11895 |
Foliglurax hydrochloride |
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11894 |
Foliglurax |
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC20549 |
SHP2 inhibitor 11a-1 |
A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
|
| DC11948 |
CK2 inhibitor D11 |
A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM. |
|
| DC11858 |
BAY-678
Featured
|
BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE). |
|
| DC22877 |
CPI703 |
A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP. |
|
| DC25052 |
Src I338G-IN-3g |
A potent, selective, cell-permeable I338G v-Src inhibitor with IC50 of 430 nM, shows no inhibition of wild-type v-Src at 300 uM. |
|
| DC21474 |
PF-04781340 |
A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
|
| DC22708 |
VU 0255035 |
A potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
|
| DC22667 |
mGlu5 PAM 4k |
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
|
| DC22684 |
JNJ-46778212
Featured
|
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM. |
|
| DC11558 |
DLK-IN-14 |
A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM. |
|
| DC11870 |
RORγt-IN-9a |
A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays. |
|
| DC22730 |
JNJ-42253432 |
A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
|
| DC22903 |
SW-106
Featured
|
SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM. |
|
| DC11898 |
Gosogliptin |
A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
|
| DC11899 |
Gosogliptin dihydrochloride |
A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
|
| DC23069 |
KRAS G12C inhibitor 1 |
A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
|
| DC21442 |
ONO 2050297 |
A potent, selective, dual CysLT1 and CysLT2 antagonist with IC50 of 17 and 0.87 nM, respectively.. |
|
| DC11666 |
BMS-470539 |
A potent, selective, full agonist of human and murine MC1R with EC50 of 16.8 and 11.6 nM, respectively. |
|
| DC20736 |
AZD 9272 |
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM. |
|
| DC20723 |
AZD 2066 |
A potent, selective, highly CNS-penetrant mGluR5 antagonist. |
|
| DC11721 |
PF-06747775 |
A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. |
|
| DC22679 |
CM 572 |
A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors. |
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