| DC22695 |
BRL 44408 maleate |
A potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors. |
|
| DC22694 |
ARC 239 dihydrochloride |
A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors. |
|
| DC22536 |
CFMTI
Featured
|
A potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively. |
|
| DC22753 |
NS13001
Featured
|
A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively. |
|
| DC11745 |
BMS-22 |
A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM. |
|
| DC11744 |
CCR2-RA-[R] |
A potent, selective, allosteric CCR2 antagonist with IC50 of 103 nM.. |
|
| DC21316 |
ML400 |
A potent, selective, allosteric LMPTP inhibitor with IC50 of 1.68 uM, displays good selective against other phosphatases. |
|
| DC22916 |
JNJ-10397049 |
A potent, selective, and bioavailable OX2 receptor antagonist with Kb of 4.5 nM. |
|
| DC23971 |
LY450108 |
A potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.. |
|
| DC24030 |
LY451395
Featured
|
A potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.. |
|
| DC23963 |
QL-47 |
A potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM. |
|
| DC21545 |
PXS-4681A |
A potent, selective, and irreversible inhibitor of SSAO/VAP-1 (AOC3) with Ki of 37 nM, IC50 of <10 nM. |
|
| DC11850 |
MK-7145 |
A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM. |
|
| DC11727 |
RO-2468 |
A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM. |
|
| DC11728 |
RO-5353 |
A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM. |
|
| DC21254 |
LY-517717 |
A potent, selective, and orally bioavailable factor Xa (FXa) inhibitor for prevention and treatment of thromboembolic diseases.. |
|
| DC21487 |
PF-05190457
Featured
|
A potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36. |
|
| DC23541 |
IRAK4-IN-16 |
A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively. |
|
| DC23949 |
CX-6258 hydrochloride hydrate |
A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively. |
|
| DC23036 |
BI-69A11 |
A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1. |
|
| DC22651 |
PF-4950834 |
A potent, selective, ATP-competitive and orally acitve Rho kinase inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively. |
|
| DC23867 |
PF-00337210 |
A potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively. |
|
| DC11711 |
VER-158411 |
A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively. |
|
| DC11733 |
SAR-020106 |
A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM. |
|
| DC12007 |
SOMG-833 |
A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM. |
|
| DC23930 |
Bay 65-1942 |
A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM. |
|
| DC22500 |
Bay 65-1942 hydrochloride |
A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM. |
|
| DC23070 |
MAP4K4-IN-11e |
A potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases. |
|
| DC23964 |
BMS-509744 |
A potent, selective, ATP-competitive ITK inhibitor with IC50 of 19 nM. |
|
| DC22551 |
DFMTI |
A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
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