PF-06827443

  Cat. No.:  DC11116  
Chemical Structure
2115022-67-6
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More than 5000 active chemicals with high quality for research!
Field of application
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.
Cas No.: 2115022-67-6
Chemical Name: 2-((3R,4S)-3-Hydroxytetrahydro-pyran-4-yl)-5-methyl-6-(4-oxazol-4-yl-benzyl)-2,3-dihydro-isoindol-1-one
Synonyms: PF06827443
SMILES: C(=O)1C2=C(C=C(C)C(CC3=CC=C(C4=COC=N4)C=C3)=C2)CN1[C@@H]1CCOC[C@H]1O
Formula: C24H24N2O4
M.Wt: 404.466
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM; induces cholinergic adverse events and convulsion at therapeutic indices similar to previous compounds with more agonist activity.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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