ND-378

  Cat. No.:  DC11630  
Chemical Structure
1807453-72-0
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective MMP-2 inhibitor with Ki of 230 nM.
Cas No.: 1807453-72-0
Chemical Name: N-(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)benzyl)acetamide
Synonyms: ND378;ND 378
SMILES: C(NCC1=CC=C(OC2=CC=C(S(CC3CS3)(=O)=O)C=C2)C=C1)(=O)C
Formula: C18H19NO4S2
M.Wt: 377.473
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective MMP-2 inhibitor with Ki of 230 nM; does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM); can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47568 ADAM8-IN-1 ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.
DC46499 CP-544439 CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM.
DC46250 FFAGLDD TFA FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
DC46249 FFAGLDD FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
DC41852 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM.
DC29148 GPLGIAGQ TFA GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).
DC29147 GPLGIAGQ GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).
DC28327 PF-00356231 hydrochloride PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.
DC28288 XL-784 free base XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively.
DC28205 UK-370106 UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM) and has little effect on keratinocyte migration in vitro.
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