Cat. No. | Product name | CAS No. |
DC73783 |
ATUX-792
ATUX-792 is a small molecule activator of protein phosphatase 2A (PP2A), decreases survival, proliferation, and motility of neuroblastoma in vitro and tumor growth in vivo. |
2088956-21-0 |
DC73784 |
CNBCA
CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes. |
|
DC73785 |
DS-1211
DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM. |
2062664-81-5 |
DC73786 |
HN252
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
|
DC73787 |
JAB-3068
JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2. |
2169223-48-5 |
DC73788 |
K161
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
2396446-12-9 |
DC73789 |
K306
K306 is a specific, small molecule agonist of SH2-containing 5' inositol phosphatase 1 (SHIP1) with EC50 of 119 nM, 10-fold higher selectivity over SHIP2. |
1184987-29-8 |
DC73790 |
NGD61181
NGD61181 is a pyrazole-based SHIP2 inhibitor, has micromolar binding affinity and inhibitory activity, does not contain a phosphatase “warhead,” binds the active site of SHIP2. |
1266401-14-2 |
DC73791 |
NSC49L
NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. |
64401-41-8 |
DC73792 |
NSC74429
Featured
NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay. |
7255-94-9 |
DC73793 |
SBI-221
SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
1840947-78-5 |
DC73794 |
SBI-668
SBI-668 is a selective inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM in isothermal CETSA assays, 7-fold selectivity over SHP2-WT (IC50=15 uM). |
|
DC73795 |
Sanofi-14h
Sanofi-14h is a selective inhibitor of the AGC family kinase SGK3, blocks DMXAA-stimulated IRF3-promoter activity with IC50 of 1.73 uM, inhibits IFNβ production under STING stimulation. |
1426214-64-3 |
DC73796 |
(R)-SW203668
(R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM). |
1673558-51-4 |
DC73797 |
TPT-004
TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively. |
|
DC74592 |
DL-Thiorphan
Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity. |
76721-89-6 |
DC74593 |
ACT001(DMAMCL)
ACT001(DMAMCL, dimethylaminomicheliolide) is a PAI-1 inhibitor and exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo. It also exerts synergistic effects in combination with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. |
1403357-81-2 |
DC74620 |
OATD-02
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study. |
2146132-73-0 |