Cat. No. | Product name | CAS No. |
DC7861 |
(-)-Narwedine
Featured
Galantamine(Narwedin) is a competitive and reversible cholinesterase(AChE) inhibitor. |
510-77-0 |
DC9090 |
Galanthamine hydrobromide
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. |
1953-04-4 |
DC10883 |
GI254023X
Featured
GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively. |
260264-93-5 |
DC8118 |
GKT137831(Setanaxib)
Featured
GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis. |
1218942-37-0 |
DC11009 |
GLX351322
Featured
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M. |
835598-94-2 |
DC7135 |
GM6001 (galardin, ilomastat)
Featured
GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM. |
142880-36-2 |
DC8767 |
GSK256066
Featured
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. |
801312-28-7 |
DC8589 |
PAD4 inhibitor GSK484
Featured
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. |
1652591-81-5 |
DC10967 |
HET0016
HET0016 (HET-0016) is a potent, selective inhibitor of CYP4A, potently inhibits the formation of 20-HETE with IC50 of 8.9 nM in human renal microsomes. |
339068-25-6 |
DC9329 |
(±)-Huperzine A
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). |
120786-18-7 |
DC12262 |
H-Val-Pro-Pro-OH TFA
H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. |
|
DC7676 |
IBMX(NSC165960; SC2964)
Featured
IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist. |
28822-58-4 |
DC10538 |
IDH-305
Featured
IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. |
1628805-46-8 |
DC10830 |
IDH-889
Featured
IDH889 is a potent and selective inhibitors of IDH1. IDH899 shows IDH (R132H) IC50 = 20 nM; Cell 2-HG IC50 = 14 nM. |
1429179-07-6 |
DC10098 |
IDO-IN-1
Featured
IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM). |
914638-30-5 |
DC10421 |
IDO-IN-2
Featured
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell. |
1668565-74-9 |
DC7015 |
INCB024360 analogue(IDO-IN-1)
Featured
INCB024360 is a potent IDO1 inhibitor(IC50=10 nM) with desirable pharmaceutical properties, which is poised to start clinical trials in cancer patients. |
914471-09-3 |
DC10866 |
Irosustat(STX64)
Featured
Irosustat(STX64) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. |
288628-05-7 |
DCAPI1578 |
Irsogladine maleate
Irsogladine maleate is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. It is a potent inhibitor of angiogenesis in wild-type and plasminogen activator-deficient mice. |
84504-69-8 |
DC11404 |
JNJ0966
Featured
JNJ0966 is a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. |
315705-75-0 |
DC9662 |
JNJ-42165279
Featured
JNJ-42165279 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70nM. |
1346528-50-4 |
DC11190 |
JTT-551
JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
776309-04-7 |