| DC7574 |
FIPI
Featured
|
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). |
|
| DC11526 |
Praliciguat
Featured
|
Praliciguat (IW-1973, IW1973) is a potent, orally available sGC stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM. |
|
| DC9107 |
Racecadotril
Featured
|
Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. |
|
| DC9128 |
Ramipril |
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
|
| DC10878 |
Raphin1
Featured
|
Raphin1 is an orally available selective phosphatase inhibitor improves proteostasis and
diminishes deficits in a mouse model of Huntington’s disease. |
|
| DC11528 |
Razuprotafib
Featured
|
Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor.. |
|
| DC11549 |
Razuprotafib sodium |
Razuprotafib sodium is a potent protein tyrosine phosphatase β(HPTPβ) inhibitor.. |
|
| DC5108 |
BAY 59-7939 (Rivaroxaban)
Featured
|
Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
|
| DCAPI1435 |
Rivastigmine tartrate |
Rivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and Parkinson's disease. |
|
| DC12051 |
RMC-4550
Featured
|
RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM. |
|
| DC9454 |
Ro 28-1675 |
Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM. |
|
| DC9686 |
Ro 41-1049 hydrochloride
Featured
|
Ro 41-1049 hydrochloride is a selective, reversible inhibitor of MAO-A. |
|
| DC7656 |
Ro 61-8048
Featured
|
Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM). |
|
| DC4146 |
Roflumilast
Featured
|
Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM. |
|
| DC11159 |
Roxyl-WL |
Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM. |
|
| DC11671 |
RPL-554 |
RPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively. |
|
| DC4134 |
Safinamide |
Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. |
|
| DC8875 |
Saxagliptin
Featured
|
Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. |
|
| DC7670 |
SB-3CT
Featured
|
SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
|
| DC8048 |
SEP-0372814
Featured
|
SEP-0372814 is a potent PDE10 inhibitor. |
|
| DC10004 |
SHP099 free base
Featured
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
|
| DC9737 |
SHP099 hydrochloride
Featured
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
|
| DC9779 |
Sildenafil citrate
Featured
|
Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. |
|
| DCAPI1349 |
Simvastatin (Zocor)
Featured
|
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
|
| DC9690 |
Sinogliatin (HMS5552, RO5305552)
Featured
|
Sinogliatin (HMS5552, RO5305552) is a mall molecule glucokinase (GCK; GK) activator. |
|
| DC8592 |
Sivelestat (sodium salt hydrate)
Featured
|
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
|
| DC10713 |
S-methyl-KE-298
Featured
|
S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
|
| DC7298 |
MY-5445 |
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM). |
|
| DC9590 |
SPK-601 |
SPK-601(LMV-601) is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; SPK-601 is useful antimicrobial agent.
|
|
| DC10956 |
sPLA2-X inhibitor 31 |
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively. |
|
