Cat. No. | Product name | CAS No. |
DC11191 |
JTT-551 sodium
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
|
DC10536 |
KML-29
Featured
KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). |
1380424-42-9 |
DC12108 |
KP-457
Featured
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and 5050s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MM |
1365803-52-6 |
DC7934 |
L-006,235
Featured
L 006235 is a reversible and potent cathepsin K inhibitor that displays more than a 4000 fold selectivity over cathepsins B, L and S. |
294623-49-7 |
DC7801 |
LB-100
Featured
LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
1632032-53-1 |
DC7707 |
LCZ-696
Featured
LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). |
936623-90-4 |
DC8688 |
Leupeptin hemisulfate
Featured
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin. Leupeptin hemisulfate is an orally active, antioxidant and anti-inflammatory agent. |
103476-89-7 |
DC1105 |
Linagliptin (BI-1356)
Featured
Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. |
668270-12-0 |
DC9123 |
Lisinopril Dihydrate
Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. |
83915-83-7 |
DC10836 |
LMPTP inhibitor 23
Featured
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
1908414-82-3 |
DC10665 |
LSN3154567(Nampt-IN-1)
Featured
LSN3154567 is a novel inhibitor of NAMPT with IC50 of 18 nM (NCI-H1155 cell), 49 nM (Calu-6 cell), 333 nM (HCC1937 cell), and 389 nM (MCF-7 cell), respectively. |
1698878-14-6 |
DC12117 |
Luteolin 7-O-glucuronide (Luteolin 7-glucuronide4)
Featured
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
29741-10-4 |
DC12118 |
Luteolin-3-O-beta-D-glucuronide
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position. |
53527-42-7 |
DC7456 |
LX1606 Hippurate
Featured
LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. |
1137608-69-5 |
DC2045 |
LY2183240
LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). |
874902-19-9 |
DC5180 |
LY2811376
Featured
LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM. |
1194044-20-6 |
DC5053 |
LY2886721
Featured
LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
1262036-50-9 |
DC7526 |
Varespladib
Featured
LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3. |
172732-68-2 |
DC8031 |
Marimastat
Marimastat is a broad spectrum MMP inhibitor and selective TACE inhibitor |
154039-60-8 |
DC11338 |
MMP-2/MMP-7 Fluorogenic Substrate Control
Featured
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. |
140430-55-3 |
DC11419 |
Merimepodib
Featured
Merimepodib(VX-497) is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase). |
198821-22-6 |
DCAPI1146 |
Methoxsalen (Oxsoralen)
Methoxsalen (Oxsoralen) |
298-81-7 |