Metabolic Enzyme/Protease

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Cat. No.	Product Name	Field of Application
DC7801	LB-100 Featured	LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
DC7707	LCZ-696 Featured	LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
DC8688	Leupeptin hemisulfate Featured	Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin. Leupeptin hemisulfate is an orally active, antioxidant and anti-inflammatory agent.
DC1105	Linagliptin (BI-1356) Featured	Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
DC9123	Lisinopril Dihydrate	Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
DC10836	LMPTP inhibitor 23 Featured	LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP.
DC10665	LSN3154567(Nampt-IN-1) Featured	LSN3154567 is a novel inhibitor of NAMPT with IC50 of 18 nM (NCI-H1155 cell), 49 nM (Calu-6 cell), 333 nM (HCC1937 cell), and 389 nM (MCF-7 cell), respectively.
DC12117	Luteolin 7-O-glucuronide (Luteolin 7-glucuronide4) Featured	Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
DC12118	Luteolin-3-O-beta-D-glucuronide	Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
DC7456	LX1606 Hippurate Featured	LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
DC2045	LY2183240	LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM).
DC5180	LY2811376 Featured	LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM.
DC5053	LY2886721 Featured	LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
DC7526	Varespladib Featured	LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3.
DC8031	Marimastat	Marimastat is a broad spectrum MMP inhibitor and selective TACE inhibitor
DC11338	MMP-2/MMP-7 Fluorogenic Substrate Control Featured	Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7.
DC11419	Merimepodib Featured	Merimepodib(VX-497) is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase).
DCAPI1146	Methoxsalen (Oxsoralen)	Methoxsalen (Oxsoralen)
DC9110	Mevastatin	Mevastatin (Compactin; ML236B) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans.
DC3158	Milrinone Featured	Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE
DC8041	MK-0941 Featured	MK-0941 is a novel Glucokinase activator (GKA)
DC7585	Omarigliptin Featured	MK-3102 (MSD) is a novel DPP-4 Inhibitor, which improves glycaemic control with low risk of symptomatic hypoglycaemia.
DC5034	MK8245 Featured	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
DC9901	Verubecestat (MK-8931) Featured	MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
DC9874	ML-348(ML348) Featured	ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
DC10747	ML355 Featured	ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.
DC12255	MLN-4760 Featured	MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
DC11368	MMP-2/MMP-9 Inhibitor II	MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively).
DC11343	MMP-2/MMP-9 Inhibitor III	MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 10-20 μM for both).
DC11355	MMP-3 Inhibitor Featured	MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.

Metabolic Enzyme/Protease

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