| DC46393 |
JNJ-67856633
|
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. JNJ-67856633 in some cases lead to tumor stasis. |
| DC73799 |
MLT-943
|
MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM. |
| DC73798 |
MLT-827
|
MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM. |
| DC72804 |
Z-VRPR-FMK
|
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression. |
| DC72411 |
RGT-068A
|
RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor. |
| DC72232 |
NVS-MALT1
|
NVS-MALT1 is a MALT1 allosteric inhibitor. |
| DC70983 |
(R)-MLT-985
|
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells. |
