DCZ0415

  Cat. No.:  DC28670   Featured
Chemical Structure
2242470-43-3
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More than 5000 active chemicals with high quality for research!
Field of application
DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.
Cas No.: 2242470-43-3
Chemical Name: DCZ0415
Synonyms: DCZ0415;BCP33607;4-[4-(Pyridin-4-ylmethyl)phenyl]-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione
SMILES: O=C1C2([H])C([H])(C(N1C1C([H])=C([H])C(C([H])([H])C3C([H])=C([H])N=C([H])C=3[H])=C([H])C=1[H])=O)C1([H])C([H])=C([H])C2([H])C2([H])C([H])([H])C21[H]
Formula: C23H20N2O2
M.Wt: 356.4171
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_12722_DC28670_2242470-43-3
COA
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Cat. No. Product name Field of application
DC71825 Chitosan oligosaccharide Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
DC44584 TCEP Hydrochloride TCEP (Tris(2-carboxyethyl)phosphine) hydrochloride, a non-thiol reducing agent, promotes NF-κB-DNA binding in a dose-related manner.
DC28670 DCZ0415 DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.
DC28480 Urolithin B Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.
DC8872 Iguratimod Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.
DC11926 NDMC101 A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
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