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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC20594 (R)-ZINC-3573 Featured (R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases.
DC9581 (S)-(+)-Rolipram (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.
DC26029 (S)-4CPG (S)-4CPG, also known as (S)-4-Carboxyphenylglycine, is a novel orally active metabotropic glutamate receptor 1 antagonist.
DC23811 (S)-BAY-293(BAY293 S-enantiomer) (S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound..
DC20595 (S)-FQI1 (S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.
DC9368 (S)-Gossypol (acetic acid) (S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
DC20017 (S)-Mapracorat (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
DC12085 (S)-Metolachor (S)-Metolachor, a derivative of aniline, is a major pesticide in use.
DC9137 Timolol Maleate Featured (S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).
DC24129 (S)-Willardiine (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM..
DC26120 (Z)-4-hydroxy Tamoxifen Featured (Z)-4-hydroxy Tamoxifen is a major phase I metabolite of tamoxifen, a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
DC10396 (Z)-Mutagenic Impurity of Tenofovir Disoproxil (Z)-Mutagenic Impurity of Tenofovir Disoproxil is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucia
DC20577 Valemetostat Featured .Valemetostat is an antineoplastic agent.
DC20486 OxPAPC 2 .
DC20487 OxPAPC 3 .
DC20488 OxPAPC 4 .
DC20485 OxPAPC 1 .
DCQ-020 Oroxylin A Featured >98%,Standard References
DC55150 Gentiopicroside Featured Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects.
DC82022 Reserpine Featured Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
DC3135 Carumonam sodium 0
DC4150 Menotrophin Featured 0
DC20187 1, 10-Phenanthroline monohydrate;Phenanthroline monohydrate 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.
DC20165 1,2,3,4,5,6-Hexabromocyclohexane;NSC7908 1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range.
DC12179 1,2-Dipalmitoyl-sn-glycerol 3-phosphate 1,2-Dipalmitoyl-sn-glycerol 3-phosphate is a phosphatidic acid.
DC12239 1,3-Diaminopropane 1,3-Diaminopropane, a three carbon diamine, is an ornithine decarboxylase inhibitor.
DC20292 103D5R 103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
DC20094 10-Hydroxydecanoic acid (NSC 15139) Featured 10-Hydroxydecanoic acid (NSC 15139) is a saturated fatty acid of 10-hydroxy-trans-2-decenoic acid from royal jelly, with anti-inflammatory activity.
DC20597 10-NCP 10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).
DC9482 17-AAG Featured 17-AAG (17-N-Allylamino-17-demethoxygeldanamycin), also known by its NSC number 330507 and CP number 127374, is a well-studied inhibitor of Heat Shock Protein 90 (HSP90). HSP90 is a molecular chaperone that plays a critical role in the stabilization and activation of a wide range of client proteins, many of which are involved in oncogenic processes. By inhibiting HSP90, 17-AAG disrupts the function of these client proteins, leading to the degradation of oncogenic proteins and ultimately inhibiting cancer cell growth and survival.

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