Novel inhibitors

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Cat. No.	Product Name	Field of Application
DC9918	Gracillin	Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent.
DC12095	GRGDSP TFA	GRGDSP (TFA) is an integrin inhibitor.
DC22629	GRL-0617 Featured	GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.
DC23564	GS 462808	GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM.
DC21070	GS-1	GS-1 is a close structural analog of GS-5806 that acts an RSV fusion inhibitor.
DC21068	GS-493	GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.
DC23381	GS-626510	GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.
DC21071	GS-9451	GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
DC23244	GS-9695	GS-9695 is a potent, non-catalytic site HIV integrase inhibitor with wild type EC50 of 1.2 nM..
DC11297	GS-9822	GS-9822 is a novel, potent NCINI with a higher barrier to resistance relative to early prototype NCINIs, including GS-9695.
DC23876	GSA-10 Featured	GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
DC9515	PI3K inhibitor GS1059615	GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively.
DC7422	GSK1292263 Featured	GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes.
DC2069	IGF-1R inhibitor GS1904529A	GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.
DC9943	PI3Kδ inhibitor GS2269557	GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms.
DC9944	PI3Kδ inhibitor GS2292767	GSK2292767 is a potent and selective PI3Kδ inhibitor.
DC9712	Iinerixibat	GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) .
DC7650	GSK2334470 Featured	GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.
DC8520	GSK-25 Featured	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
DC9719	Lp-PLA2 -IN-1(GSK2814338) Featured	GSK2814338, also known as Lp-PLA2 -IN-1, is a Lp-PLA2 inhibitor
DC9721	GSK2983559 active metabolite Featured	GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
DC9717	amyloid P-IN-1(GSK3039294) Featured	GSK3039294 is a Serum amyloid P component inhibitor.
DC10391	EBI2 inhibitor GS682753A	GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
DC2070	GSK690693 Featured	GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.
DC26130	GSK8612 Featured	GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
DC10061	PI4KA inhibitor-A1 Featured	GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM.
DC10064	GSK-F1 Featured	GSK-F1 is a potent inhibitor of PI4KA.
DC7858	GSK-J1 Featured	GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro).
DC23890	GSM-1	GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
DC23886	GSM-2	GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.

Novel inhibitors

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