Novel Selective CYP17A1 Lyase Inhibitor

Prodrug of the novel fluoro-substituted camptothecin analog, BMS-286309

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Novel, potent, exceptionally selective inhibitor of TNF-α Converting Enzyme (TACE)

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel Novel γ-secretase modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Potent, Orally Bioavailable, Metabolically Stable Thumb Site 1 Inhibitor of the Hepatitis C Virus NS5B RNA-Dependent, RNA Polymerase

Novel potent and selective P2Y1 purinergic receptor antagonist.

Novel inhibitor of the influenza nucleoprotein (INF-NP)

Potent alpha7 Nicotinic receptor partial agonist, improving cognition in preclinical rodent model

Potent and selective GPR119 agonist

Novel Agonist of Sphingosine-1-Phosphate (S1P1)

Selective RARγ agonist

Novel GPR119 agonist

Novel S1P1 receptor modulator

Novel γ-secretase modulator

Novel pan-genotype inhibitor of HCV NS5B polymerase via binding to the primer grip site

G-quadruplex ligand, decreasing oncogene expression