DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC24065 | EPZ-011989 trifluoroacetate | A potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
|
| DC23552 | AS-2444697 HCl Featured | A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1. |
|
| DC11835 | AM-8553 | A potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM. |
|
| DC11677 | CCT-271850 | A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM. |
|
| DC22941 | AZD-9056 | A potent, selective, orally bioavailable P2X7 receptor antagonist. |
|
| DC11841 | LAS191954 | A potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM. |
|
| DC21607 | SB-649868 Featured | SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). |
|
| DC21598 | RWJ-56110 | A potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4. |
|
| DC20691 | ASP 3652 | A potent, selective, peripherally active and orally available FAAH inhibitor for treatment of chronic prostatitis/chronic pelvic pain syndrome.. |
|
| DC11748 | LY2033298 Featured | LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. |
|
| DC23043 | Tpl2-IN-2p | A potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase with IC50 of 50 nM. |
|
| DC23933 | MK-0893 | A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM). |
|
| DC11691 | NSC95397 Featured | A potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively. |
|
| DC11978 | SB 265610 Featured | SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. |
|
| DC20412 | II-B08 | A potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs. |
|
| DC11875 | GlpG inhibitor 11 | A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG . |
|
| DC11713 | NSC-109555 ditosylate | A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM. |
|
| DC11724 | MS-453 | A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM. |
|
| DC22892 | KNT-127 | A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively. |
|
| DC22563 | TN1 | A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM. |
|
| DC20606 | 8-Thioquinoline | A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM.. |
|
| DC11951 | Bischof-5 | A potent, specfic casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM. |
|
| DC11983 | CX797 | A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM. |
|
| DC21321 | ML349 Featured | A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family. |
|
| DC22529 | FPTQ | A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively.. |
|
| DC25075 | Sivelestat sodium | A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23074 | Sivelestat Featured | A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23494 | GRI 977143 Featured | A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
|
| DC24105 | MK-0591（Quiflapon ） Featured | A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay. |
|
| DC11556 | trans-AUCB | A potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM. |
|
