| DC20640 |
ACT 709478 |
ACT 709478 is a potent, selective, orally-bioavailable, brain penetrant T-type calcium channel blocker with IC50 of 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3 channels respectively. |
|
| DC11209 |
ACT-246475 |
ACT-246475 (ACT246475) is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM. |
|
| DC21986 |
ACT-281959 |
ACT-281959 (ACT281959) is the prodrug of ACT-246475, which is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM. |
|
| DC11439 |
Nemorexant
Featured
|
ACT-541468 is a dual orexin receptor antagonist. |
|
| DC8191 |
Sparsentan(PS433540)
Featured
|
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1]. |
|
| DC10417 |
Acumapimod (BCT197)
Featured
|
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
|
| DC20235 |
Ac-WEHD-pNA
Featured
|
Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4. |
|
| DC22659 |
ACY-775 |
ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability. |
|
| DC11008 |
ACY-957 |
ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM). |
|
| DCAPI1273 |
Acyclovir (Aciclovir) |
Acyclovir (Aciclovir) |
|
| DC11754 |
AD 2900
Featured
|
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
|
| DC10633 |
AD80
Featured
|
AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM. |
|
| DC20301 |
ADAMTS-5 inhibitor 15f |
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
|
| DC20302 |
ADAMTS-5 inhibitor 8 |
ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
|
| DC9362 |
Adarotene |
Adarotene (ST1926) is an effective apoptosis inducer and surprisingly produced DNA damage.ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells.
IC50 value: 0.12 uM (LNCaP cell) [1]
Target: Apoptosis inducer; Antican |
|
| DC20642 |
ADC-3680 |
ADC-3680 (PTR-36, ADC-3680B) is a potent, selective prostaglandin D2 receptor (DP2, CRTH2) antagonist for the treatment of asthma.. |
|
| DC21294 |
MK-1029 |
ADC-3680 is a potent, selective prostaglandin D2 receptor (DP2, CRTH2) antagonist for the treatment of asthma.. |
|
| DC4155 |
Adefovir Dipivoxil
Featured
|
Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. |
|
| DC10244 |
Ademetionine disulfate tosylate |
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. |
|
| DC20163 |
Adenosine 5'-monophosphate monohydrate; 5'-Adenylic acid;5'-AMP |
Adenosine 5'-monophosphate monohydrate (5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). |
|
| DC20303 |
Adhesamine |
Adhesamine is a diaryldispirotripiperazine derivative that selectively targets cell-surface glycosaminoglycans, especially heparan sulfate, for increasing cell adhesion and growth. |
|
| DC12091 |
AdipoRon hydrochloride
Featured
|
AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM, respectively. |
|
| DC7050 |
ADL5859 HCl
Featured
|
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid |
|
| DC20644 |
ADM 12 |
ADM 12 (ADM_12. |
|
| DC9324 |
Adoprazine |
Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
|
|
| DC12115 |
Adrenomedullin (AM) (1-52), human TFA (Human adrenomedullin-(1-52)-NH2 (TFA)) |
Adrenomedullin (AM) (1-52), human (TFA) affects cell proliferation and angiogenesis in cancer. |
|
| DC20645 |
ADT-094 |
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively. |
|
| DC11097 |
ADX-102 (Reproxalap;NS-2)
Featured
|
ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease. |
|
| DC5113 |
AEE-788 (NVP-AEE788)
Featured
|
AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2. |
|
| DC23140 |
AF38469
Featured
|
AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin |
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