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AF38469

  Cat. No.:  DC23140   Featured
Chemical Structure
1531634-31-7
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More than 5000 active chemicals with high quality for research!
Field of application
AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1531634-31-7
Chemical Name: Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-
Synonyms: AF-38469
SMILES: CC1=NC(NC(=O)C2C(C(O)=O)=CC(C(F)(F)F)=CC=2)=CC=C1
Formula: C15H11F3N2O3
M.Wt: 324.2546
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
Target: IC50:330 nM (Sortilin)[1]
In Vitro: AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1].
References: [1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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