| DC9278 |
CWHM-12
Featured
|
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1. |
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| DC11082 |
Danicopan (ACH-4471)
Featured
|
Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM. |
|
| DC9116 |
Dantrolene sodium |
Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. |
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| DC8188 |
Daprodustat
Featured
|
Daprodustat(GSK1278863) isa HIF-prolyl hydroxylase inhibitor. |
|
| DCAPI1107 |
Deferasirox (Exjade)
Featured
|
Deferasirox (Exjade) |
|
| DC9604 |
Desogestrel
Featured
|
Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP). |
|
| DC9434 |
DMP 777 |
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
|
|
| DC8485 |
E-64d(Aloxistatin)
Featured
|
E-64D is an inhibitor of cathepsins B and L; also thought to inhibit calpain,showed a potent activity for COVID-19(SARS-COV-2)with EC50: MERS-COV(1.275),SARS-COV(0.760) |
|
| DC10939 |
Edasalonexent |
Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA). |
|
| DC8626 |
Eluxadoline
Featured
|
Eluxadoline is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. |
|
| DC9771 |
ACU4429,ACU 4429,ACU-4429
Featured
|
Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. |
|
| DC10314 |
Emixustat |
Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. |
|
| DC9762 |
Emricasan
Featured
|
Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor. |
|
| DC11433 |
Vatiquinone |
EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone. |
|
| DC10040 |
Etrasimod(APD334)
Featured
|
Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1(S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
|
| DC9821 |
Ezutromid
Featured
|
Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM . |
|
| DC8912 |
Fesoterodine fumarate
Featured
|
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
|
| DC5193 |
Roxadustat(FG-4592)
Featured
|
FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. |
|
| DC11187 |
Fonadelpar |
Fonadelpar (NPS-005,SJP-0035) is a potent, selective peroxisome proliferator activated receptor δ (PPARδ) agonist for the treatment of corneal disorders.. |
|
| DC6917 |
Vonoprazan
Featured
|
For the detailed information of Vonoprazan, the solubility of Vonoprazan in water, the solubility of Vonoprazan in DMSO, the solubility of Vonoprazan in PBS buffer, the animal experiment (test) of Vonoprazan, the cell expriment (test) of Vonoprazan, the in vivo, in vitro and clinical trial test of Vonoprazan, the EC50, IC50,and affinity,of Vonoprazan, For the detailed information of Vonoprazan, the solubility of Vonoprazan in water, the solubility of Vonoprazan in DMSO, the solubility of Vonoprazan in PBS buffer, the animal experiment (test) of Vonoprazan, the cell expriment (test) of Vonoprazan, the in vivo, in vitro and clinical trial test of Vonoprazan, the EC50, IC50,and affinity,of Vonoprazan, Please contact DC Chemicals.. |
|
| DC11394 |
Fulacimstat(BAY 1142524)
Featured
|
Fulacimstat(BAY 1142524) is a small molecule chymase inhibitor. |
|
| DC9859 |
GAL-021
Featured
|
GAL-021 is a new intravenous BKCa-channel blocker. |
|
| DC10474 |
GBT-440(Voxelotor)
Featured
|
GBT-440(Voxelotor) is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity. |
|
| DC11803 |
GLPG-1690(Ziritaxestat)
Featured
|
GLPG-1690 is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM. |
|
| DC10753 |
GLPG-1837(ABBV-974)
Featured
|
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator. |
|
| DC11678 |
GLPG-2222 |
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
|
| DC9738 |
GSK2881078
Featured
|
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness. |
|
| DC10936 |
GSK3179106
Featured
|
GSK3179106 (GSK-3179106, GSK 3179106) is a potent, selective, first-in-class and gut-restricted with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively. |
|
| DC8166 |
Molidustat(BAY 85-3934)
Featured
|
Hypoxia-inducible factor prolyl hydroxylase inhibitor |
|
| DC10007 |
Ibiglustat(Genz-682452）
Featured
|
Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
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