| DC23193 |
(S)-MCPG |
The active isomer of (RS)-MCPG, an non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.. |
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| DC23990 |
N-Desethyl Sunitinib
Featured
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The active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor for the treatment of RCC and imatinib-resistant GIST.. |
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| DC9373 |
5-TAMRA
Featured
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The amine-reactive 5-TAMRA, SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability. |
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| DC9947 |
RU43044 |
The antiglucocorticoid RU43044 exerted significant agonist activity and activated MMTV-Luc transcription in osteosarcoma cells but not human breast cancer cells. |
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| DC24020 |
Calcium N5-methyltetrahydrofolate |
The calcium salt of levomefolic acid that has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. . |
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| DC21523 |
Pomstafib-1 |
The cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a. |
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| DC8509 |
Akt-I-1
Featured
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The compound (Akt-I-1) inhibits only Akt1 (IC50 4.6 μM) and does not inhibit AKT2, or AKT3. |
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| DC20956 |
DM-NOFD |
The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
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| DC20291 |
(S)-BRS-3 agonist Compound A |
The distomer of BRS-3 agonist Compound A, shows no activity for bombesin receptor subtype-3 (BRS-3) with EC50>10 uM.. |
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| DC23959 |
Aliskiren
Featured
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The first in a class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM. |
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| DC20396 |
GPR4 antagonist 3b |
The first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM). |
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| DC11818 |
SCB-4380
Featured
|
SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis.
SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6.
SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model. |
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| DC11626 |
Sulfotransferase-IN-1 |
The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM . |
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| DC26077 |
EG00229
Featured
|
The first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1). |
|
| DC8854 |
ARS-853 intermediate
Featured
|
The intermediate of ARS-853.ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
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| DC23116 |
(S)-GNE-140 |
The less active enantiomer of GNE-140, inhibits LDHA activity (18-fold less potent that (R)-GNE-140). |
|
| DC21410 |
Phortress |
The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway. |
|
| DC24187 |
Calcifediol monohydrate
Featured
|
The major circulating metabolite of vitamin D3. |
|
| DC22687 |
(-)-U-50488 hydrochloride |
The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects. |
|
| DC7401 |
Des(benzylpyridyl) Atazanavir
Featured
|
The N-dealkylated metabolite (M1) of Atazanavir (A790051), a HIV protease inhibitor. |
 Atazanavir.png)
|
| DC23923 |
D-Glutamic acid
Featured
|
The one form of glutamic acid found in nature, is the most potent natural inhibitor of glutathione synthesis. |
|
| DC21777 |
Candoxatril |
The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.. |
|
| DC21061 |
GPA 512 |
The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. |
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| DC23916 |
Human growth hormone-releasing factor
Featured
|
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. |
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| DC21524 |
Pomstafib-2 |
The pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM. |
|
| DC23007 |
AUDA-BE |
The prodrug of AUDA, a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 50 nM and 100 nM for mouse sEH and human sEH, respectively. |
|
| DC25073 |
Cidofovir dihydrate |
The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases. |
|
| DC24002 |
Adrafinil
Featured
|
The prodrug of modafinil that is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention.. |
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| DC23955 |
PF-04929113 Mesylate |
The prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor. |
|
| DC23989 |
TG 100801 hydrochloride |
The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
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