| DC34437 |
Tyrphostin AG957 |
Tyrphostin AG957 is a tyrosine kinase inhibitor, selectively inhibiting human p210 tyrosine kinase activity. |
|
| DC34438 |
Blebbistatin |
(±)-Blebbistatin is a cell cycle inhibitor and a selective inhibitor of non-muscle myosin II. |
|
| DC34439 |
5-CFDA |
5-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells. |
|
| DC34440 |
6-CFDA |
6-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells. |
|
| DC34441 |
Epigenetic Multiple Ligand |
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation. |
|
| DC34442 |
BAY32-5915 |
BAY32-5915 is an IKKalpha inhibitor. |
|
| DC34443 |
Cilostamide |
Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). |
|
| DC34444 |
Clofilium Tosylate |
Clofilium Tosylate is a K+ channel blocker, cardiac depressant, and anti-arrhythmic agent. |
|
| DC34445 |
Ranitidine-N-oxide |
Ranitidine-N-oxide is a metabolite of Ranitidine. Ranitidine is a histamine H2-receptor antagonist, inhibiting the normal and meal-stimulated secretion of stomach acid. Ranitidine, sold under the trade name Zantac among others, is a medication which decreases stomach acid production. |
|
| DC34446 |
Iprovalicarb |
Iprovalicarb is a fungicide specific to oomycetes. |
|
| DC34447 |
NVS-CECR2-1 |
NVS-CECR2-1 is a potent and selective CECR2 inhibitor. |
|
| DC34448 |
UK-78282 Hydrochloride |
UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels. |
|
| DC34449 |
Dofequidar fumarate |
Dofequidar fumarate is a potent inhibitor of MDR-1. |
|
| DC34450 |
Fendiline Hydrochloride |
Fendiline HCl is a potent acid sphingomyelinase (ASM) inhibitor, reducing the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane and inhibiting calcium function in muscle cells in excitation-contraction coupling. |
|
| DC34451 |
HDAC8-IN-2 |
HDAC8-IN-2 is a selective HDAC8 inhibitor. |
|
| DC34452 |
Aloenin |
Aloenin is a moderate inhibitor of BACE. |
|
| DC34453 |
PF-06424439
Featured
|
PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1. PF-06424439 demonstrated excellent ADMET properties and decreased circulating and hepatic lipids when orally administered to dyslipidemic rodent models. PF-06424439 inhibited DGAT2 of different species (human, rat, and dog) with similar potency. Among related acyltransferases, no significant inhibition was observed for PF-06424439 (up to 50 μM) against human MGAT2 or MGAT3, DGAT1, or mouse MGAT1, indicating a high selectivity (>2000-fold) against these enzymes. |
|
| DC34455 |
TP2 |
TP2 is an inhibitor of polyketide synthase 13 (Pks13), preventing synthesis of mycolic acid and resulting in mycobacterial cell death. |
|
| DC34456 |
Neurodazine |
Neurodazine is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons. |
|
| DC34457 |
Nalmefene Hydrochloride |
Nalmefene HCl is an antagonist of the opioid receptors. |
|
| DC34458 |
EPPS |
EPPS is a rescuer of A? aggregation and behavioural deficits, binding to A? aggregates and converting them into monomers. |
|
| DC34459 |
ADP Sodium Salt |
ADP Sodium is an adenine nucleotide, converting into ATP by ATP synthases, affecting platelet activation through its interaction with P2Y1, P2Y12 and P2X1. |
|
| DC34460 |
C8 Ceramide |
C8 Ceramide is a cell-permeable analog of naturally occurring ceramides. |
|
| DC34461 |
IMB-10 |
IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo. |
|
| DC34462 |
PF-5274857 HCl |
PF-5274857 HCl is a potent and selective smoothened (Smo) receptor antagonist. |
|
| DC34463 |
Milbemycin A3 Oxime |
Milbemycin A3 Oxime is an opener of glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and blocking signal transfer. Milbemycin A3 Oxime is also an anthelmintic. Formulations containing milbemycin A3 oxime, in combination with milbemycin A4 oxime, have been used in the treatment of parasitic infections in dogs. |
|
| DC34464 |
SKI-II Hydrochloride |
SKI-II HCl is a substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase. |
|
| DC34465 |
ACT-678689 |
ACT-678689 is a potent inhibitor of tryptophan hydroxylase 1 (TPH1). |
|
| DC34466 |
Toltrazuril |
Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals. |
|
| DC34467 |
FAD-Na2 |
FAD-Na2 is a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating flavoprotein monooxygenases. |
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