| DC50300 |
Stachybotrysin B |
Stachybotrysin B is a phenylspirodrimane derivative. Stachybotrysin B is isolated from Stachybotrys chartarum CGMCC 3.5365. |
|
| DC50301 |
Diallyl disulfide |
Diallyl disulfide inhibits human squalene monooxygenase with an IC50 of 400 μM for squalene epoxidation. |
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| DC50302 |
2,3-Dihydro-3-methoxywithaferin A |
2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells. |
|
| DC50303 |
Methyl tetracosanoate |
Methyl tetracosanoate is used as an analytical standard in chromatographic assays. |
|
| DC50304 |
Gluconapin potassium |
Gluconapin potassium is the precursor of sulforaphane. Sulforaphane is a potent anti-cancer isothiocyanate. |
|
| DC50305 |
OB3 |
OB3, a derivative of Leptin, show more effective than leptin in reducing obesity and diabetes in mouse models. OB3 can reduce Leptin-related inflammation and proliferation in hepatocellular carcinoma cells. |
|
| DC50306 |
Hortein |
Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba. |
|
| DC50307 |
Tajixanthone |
Tajixanthone is the fungus metabolite from Aspergillus variecolor. |
|
| DC50308 |
Mycestericin C |
Mycestericin C is a compound isolated from the culture broth of Mycelia sterilia ATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction. |
|
| DC50309 |
Muristerone A |
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a Kd of 1 nM. |
|
| DC50310 |
(-)-(E)-Guggulsterone |
(-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic drug derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity. |
|
| DC50311 |
Agonodepside B |
Agonodepside B is a compound isolated from a nonsporulating filamentous fungus, F7524. |
|
| DC50312 |
Anhydroophiobolin A |
Anhydroophiobolin A is a potent inhibitor of photosynthesis with IC50s of 77 and 14 mM in the photosynthesis of chlorella and spinach, respectively. Anhydroophiobolin A is an analog of Ophiobolin A. |
|
| DC50313 |
Glucoarabin |
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity. |
|
| DC50314 |
Choline oxidase |
Choline oxidase catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production. |
|
| DC50315 |
Aspulvinone O |
Aspulvinone O is a natural inhibitor of aspartate transaminase 1 (GOT1). GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 may serve as an important target in PDAC. Aspulvinone O suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. |
|
| DC50316 |
11-O-Methylpseurotin A |
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain. |
|
| DC50317 |
γ-AA peptide P6 (Cyclic γ-AA Peptide 6)
Featured
|
γ-AA peptide P6 (Cyclic γ-AA P6) is a potent activator of E6 associated protein (E6AP). γ-AA peptide P6 can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions in vitro. γ-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome. |
|
| DC50318 |
3-(2-Hydroxyethyl) thio withaferin A |
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. |
|
| DC50006 |
Cinobufagin (Cinobufagine)
Featured
|
Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2]. |
|
| DC50007 |
Etoposide
Featured
|
>98%,Standard References |
|
| DC50008 |
Colchicine
Featured
|
Colchicine is a potent therapeutic tool against COVID-19. Colchicine is a tricyclic alkaloid that is extracted from the plant Colchicum autumnale. Colchicine acts as a potent inhibitor of tubulin polymerization. |
|
| DC71257 |
HXR9 hydrochloride |
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells. |
|
| DC72109 |
W-7 isomer hydrochloride |
W-7 isomer hydrochloride is an isomer of W-7 hydrochloride. W-7 hydrochloride is a selective calmodulin antagonist.
|
|
| DC72133 |
cis-Epoxysuccinic acid |
cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system. |
|
| DC72254 |
BMT-090605 hydrochloride |
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain. |
|
| DC72261 |
A-446 |
A-446 is a potent glutaminase (GLS) inhibitor with an IC50 value of 31 nM. |
|
| DC72269 |
Tri-GalNAc(OAc)3 TFA
Featured
|
Tri-GalNAc(OAc)3 TFA is a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera. |
|
| DC72277 |
Elvucitabine |
Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection. |
|
| DC72736 |
Hi76-0079 |
Hi 76-0079 (NNC0076-0079) is a specfic, small molecule inhibitor of hormone-sensitive lipase (HSL) with IC50 of 0.11 uM. |
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