| DC21853 |
Ogerin
Featured
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A selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65. |
|
| DC20596 |
O-phenanthroline |
A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM. |
|
| DC22980 |
ND-336 |
A selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively. |
|
| DC21127 |
HT-0411 |
A selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2. |
|
| DC23235 |
Flupirtine |
A selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties. |
|
| DC26069 |
SR-11237
Featured
|
SR-11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. . |
|
| DC22616 |
CJ-42794
Featured
|
A selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5. |
|
| DC20567 |
Tec Kinase-IN-21 |
A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 11.7 uM. |
|
| DC20566 |
Tec Kinase-IN-14 |
A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 7.0 uM. |
|
| DC25014 |
Cysmethynil |
A selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM, does not inhibit other enzymes (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 uM. |
|
| DC20306 |
AMTB hydrochloride
Featured
|
A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6). |
|
| DC23226 |
Guanfacine |
A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone. |
|
| DC24156 |
Metoprolol |
A selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.. |
|
| DC7029 |
SC-26196
Featured
|
A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases |
|
| DC26107 |
TRV0109101 hydrochloride |
A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo.. |
|
| DC26103 |
TRV0109101 |
A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo.. |
|
| DC21728 |
TAK-070 |
A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays. |
|
| DC20995 |
EP009 |
A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM. |
|
| DC20287 |
δ-secretase inhibitor 11 |
A selective, orally bioactive and brain permeable δ-secretase (AEP. |
|
| DC22971 |
CDE 096 |
A selective, reversible, high-affinity PAI-1 inhibitor that prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively). |
|
| DC21780 |
UNC-3230 |
A selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks. |
|
| DC21400 |
NS-1209 |
A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM. |
|
| DC22451 |
AQX 1125 acetate |
A sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM. |
|
| DC23981 |
BCX-1470 methanesulfonate
Featured
|
A serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
|
| DC22666 |
Levosalbutamol |
A short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).. |
|
| DC23231 |
Levalbuterol tartrate |
A short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).. |
|
| DC22828 |
DBCO-Amine |
A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond. |
|
| DC23011 |
Shz-1 |
A small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells. |
|
| DC25018 |
Shz-3 |
A small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells. |
|
| DC21818 |
MIN-117 |
A small molecule 5-HT1A and 5-HT2A receptor antagonist and inhibitor of serotonin and dopamine reuptake, also possess affinity for the α1A- and α1B-adrenergic receptors.. |
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