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AMTB hydrochloride

  Cat. No.:  DC20306   Featured
Chemical Structure
926023-82-7
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More than 5000 active chemicals with high quality for research!
Field of application
A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 926023-82-7
Chemical Name: AMTB hydrochloride
Synonyms: AMTB hydrochloride;N-(3-AMINOPROPYL)-2-[(3-METHYLPHENYL)METHOXY]-N-(2-THIENYLMETHYL)BENZAMIDE HYDROCHLORIDE
SMILES: Cl.NCCCN(C(C1=CC=CC=C1OCC1=CC=CC=C1C)=O)CC1=CC=CS1
Formula: C23H27ClN2O2S
M.Wt: 430.990683794022
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV)[1][2].
In Vivo: In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction[1].
In Vitro: AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8)[2]. AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM)[2].
References: [1]. Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295(3):F803-F810. [2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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