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Ogerin

  Cat. No.:  DC21853   Featured
Chemical Structure
1309198-71-7
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More than 5000 active chemicals with high quality for research!
Field of application
A selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1309198-71-7
Chemical Name: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
SMILES: NC1N=C(NCC2C=CC=CC=2)N=C(C2C=CC=CC=2CO)N=1
Formula: C17H17N5O
M.Wt: 307.349782705307
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1].
Target: pEC50: 6.83 (GPR68)[1] Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]
References: [1]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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