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IT-603

  Cat. No.:  DC22984   Featured
Chemical Structure
292168-90-2
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More than 5000 active chemicals with high quality for research!
Field of application
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 292168-90-2
Chemical Name: (5E)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one
Synonyms: 5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;(5E)-5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;STL418592;(E/Z)-IT-603
SMILES: BrC1C([H])=C(C(=C(C=1[H])/C(/[H])=C1\C(N([H])C(N\1[H])=S)=O)O[H])OC([H])([H])[H]
Formula: C11H9BrN2O3S
M.Wt: 329.1698
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.
References: References 1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91. View Related Products by Target NF-κB
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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