DC20961 |
AA-861 |
AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM. |
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DC26090 |
AAD777 |
AAD777 (NVP-AAD777. |
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DC20618 |
AAI-101
Featured
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AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases. |
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DC12566 |
AAK1 inhibitor 1 |
AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE ((BMP-2 inducible kinase)) that potently targets the ATP-binding site (AAK1 Ki =9.1 nM, BIKE Ki= 17 nM). |
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DC21862 |
AAK1 inhibitor 25A |
AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1). |
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DC12400 |
AAL(S) |
AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A).. |
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DC23864 |
AAL993
Featured
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AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively. |
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DC21981 |
CD73 inhibitor AB-680
Featured
|
AB680 (AB-680) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73), displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, a |
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DC8161 |
Xeglyze(Abametapir)
Featured
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Abametapir is the active ingredient of Xeglyze Lotion. |
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DC12444 |
ABD-1970 |
ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL). |
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DC20620 |
ABD345 |
ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation. |
|
DC23586 |
Abeprazan |
Abeprazan is an acid pump inhibitor.. |
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DC24211 |
Abiraterone (D4A)
Featured
|
Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone. |
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DC20619 |
ABL127
Featured
|
ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM. |
|
DC20298 |
ABL-IN-29 |
ABL-IN-29 is a picomolar ABL kinase inhibitor with IC50 of 0.06/0.11 nM for wt ABL and ABL T315I respectively.. |
|
DC20299 |
ABMA |
ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. |
|
DC21983 |
Abn-CBD |
Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM). |
|
DC20625 |
ABT-072 |
ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b). |
|
DC22258 |
ABT-080 |
ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM. |
|
DC20626 |
ABT-089 |
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
|
DC21984 |
ABT-100 |
ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase). |
|
DC20628 |
ABT-102 |
ABT-102 is a potent, highly selective, orally active TRPV1 antagonist that inhibits agonist-evoked increases in intracellular Ca(2+) levels with IC50 of 5-7 nM. |
|
DC20629 |
ABT-107 |
ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs. |
|
DC23537 |
ABT-288 |
ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively. |
|
DC7352 |
ABT-333
Featured
|
ABT-333 is an NS5B non-nucleoside polymerase inhibitor. |
|
DC10049 |
Tebanicline(ABT-594)
Featured
|
ABT-594 represents a novel class of broad-spectrum analgesics whose primary mechanism of action is activation of the neuronal nicotinic acetylcholine receptors. |
|
DC10723 |
ABT-702
Featured
|
ABT-702 is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). |
|
DC9262 |
ABT-719
Featured
|
ABT-719 is a potent bacterial DNA gyrase inhibitor. |
|
DC9261 |
ABT-719 HCl
Featured
|
ABT-719 is a potent bacterial DNA gyrase inhibitor. |
|
DC20630 |
ABTL0812 |
ABTL0812 is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells. |
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