Cat. No. | Product name | CAS No. |
DC12224 |
H-Arg-4MβNA
H-Arg-4MβNA is a substrate for cathepsin H, used for the detection of enzyme activity in gel electrophoresis. |
60285-94-1 |
DC23634 |
HBT1
HBT1 is a novel potent AMPA receptor potentiator with lower agonistic effect compared with LY451395 and OXP1.. |
489408-02-8 |
DC20917 |
HBV Capsid inhibitor 3711
HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
2041072-40-4 |
DC23783 |
HBX 28258
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
1426544-54-8 |
DC8207 |
HBX41108
Featured
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). |
924296-39-9 |
DC5200 |
HC-030031
Featured
HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
349085-38-7 |
DC12197 |
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM). |
7733-96-2 |
DC21108 |
HC-070
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
1628291-95-1 |
DC12620 |
hClpP activator D9
Featured
hClpP activator D9 is a potent and species-selective activator of human ClpP (hClpP, human Caseinolytic protease P) by mimicking the natural chaperone ClpX.. |
950261-75-3 |
DC20401 |
HDAC6-AR-IN-10
HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM). |
2042519-10-6 |
DC21113 |
HEC72702
HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM. |
1793063-59-8 |
DC21114 |
HEC-73543
HEC-73543 is a novel potent, selective, orally bioavailable FLT3 inhibitor for the treatment of refractory acute myeloid leukemia (AML). |
|
DC9921 |
Hederacoside C
Featured
Hederacoside C is a principal bioactive pharmaceutical ingredient of Hedera helix leaf that can treat respiratory disorders, because of its expectorant, bronchodilator, antibacterial, and bronchospasmolytic effects. |
14216-03-6 |
DC9823 |
Hederagenin
Featured
Hederagenin a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases. |
465-99-6 |
DC20402 |
Hedgehog-IN-7d
Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.. |
330796-24-2 |
DC21414 |
Helenalin
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
6754-13-8 |
DC21109 |
Hemicholinium-3
Hemicholinium-3 (HC-3) is a competitive, small molecule inhibitor of choline kinase (ChoK) with ex vivo IC50 of 500 uM, also bolcks the sodium and chloride-dependent transport system and affects choline acetyltransferase. |
16478-59-4 |
DC24152 |
Hemin
Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type. |
16009-13-5 |
DC21115 |
TD-1
Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. |
1621694-21-0 |
DC12294 |
Heparin lithium salt
Featured
Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). |
9045-22-1 |
DC10422 |
Heptamethine cyanine dye-1
Heptamethine cyanine dye-1 is a near-infrared cyanine dye for fluorescence imaging in biological systems. |
162411-29-2 |
DC20403 |
HER2-IN-2
HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases. |
2011708-43-1 |
DC20404 |
HER2-IN-3
HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2. |
2011708-45-3 |
DC23730 |
Herboxidiene
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
142861-00-5 |
DCAPI1218 |
Hesperidin
Hesperidin |
520-26-3 |
DC12717 |
Hetrombopag
Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist. |
2114365-78-3 |
DC12227 |
Hexacosanoic acid
Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis. |
506-46-7 |
DC12195 |
Hexadimethrine bromide
Featured
Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
28728-55-4 |
DC12306 |
Hexamethylquercetagetin
Hexamethylquercetagetin is a polymethoxylated flavone in peels of citrus cultivars. |
1251-84-9 |
DC8680 |
Hexaminolevulinate hydrochloride
Hexaminolevulinate hydrochloride is a fluorescent agent, has approved for cystoscopic detection of papillary bladder cancer. |
140898-91-5 |
DC12707 |
Hexokinase 2 modulator Comp-1
Hexokinase 2 modulator Comp-1 is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM. |
2055404-90-3 |
DC21904 |
HG-12-6
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM). |
2222354-57-4 |
DC10652 |
HG-14-10-04
Featured
HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. |
1356962-34-9 |
DC23141 |
HG6-64-1
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively. |
1315329-43-1 |
DC20405 |
HG-7-27-01
HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases.. |
1135270-45-9 |
DC21379 |
HG-7-92-01(NG25)
Featured
HG-7-92-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases.. |
1315355-93-1 |
DC10108 |
HG-9-91-01
Featured
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
1456858-58-4 |
DC26060 |
gly-arg p-nitroanilide dihydrochloride
Featured
H-Gly-Arg-pNA is a colorimetric substrate for thrombin. |
125455-61-0 |
DC8846 |
HhAntag
Featured
HhAntag is a GLI1-Mediated transcription inhibitor. |
496794-70-8 |
DC20406 |
HIF2α-IN-2
HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function. |
1422955-31-4 |
DC7148 |
LY 379268
Featured
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. |
191471-52-0 |
DC20083 |
H-Ile-Pro-Pro-OH
H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides. |
26001-32-1 |
DC23298 |
Hinokitiol
Hinokitiol (4-Isopropyltropolone. |
499-44-5 |
DC23710 |
Hippuristanol
Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis. |
80442-78-0 |
DC10585 |
Hispidol
Featured
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
5786-54-9 |
DC8163 |
Fostemsavir(BMS-663068)
Featured
HIV-1 attachment inhibitor,a prodrug of the small-molecule inhibitor BMS-626529 |
864953-29-7 |
DC23258 |
HIV-1 inhibitor 18A
HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM. |
331261-50-8 |
DC23263 |
HIV-1 Integrase Inhibitor 7
HIV-1 Integrase Inhibitor 7 is an allosteric HIV-1 integrase inhibitor that inhibits the LEDGF/p75-integrase interaction with IC50 of 0.58 uM, antiviral activity EC50 of 0.76 uM.. |
1235379-91-5 |
DC21116 |
HJC0197
Featured
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP. |
1383539-73-8 |
DC21118 |
HJC 0726
HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM. |
1449764-45-7 |
DC21117 |
HJC-0338
HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2. |
1417718-39-8 |
DC7638 |
HJC-0350
Featured
HJC-0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells. |
885434-70-8 |
DC21119 |
HL001
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
1186371-31-2 |
DC21977 |
HlyU inhibitor CM14
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30. |
588678-13-1 |
DC10414 |
HM30181(Encequidar)
Featured
HM30181 is a potent and selective inhibitor of P-glycoprotein. |
849675-66-7 |
DC12074 |
HM30181 mesylate
Featured
HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor. |
849675-87-2 |
DC10517 |
HMN-154
Featured
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively. |
173528-92-2 |
DC9957 |
HMN-176
Featured
HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization. |
173529-10-7 |
DC20407 |
HMPC
HMPC is a novel bacteriostatic agent that shows bacteriostatic activity against S. aureus (MIC=4 μg/ml) and rescues Caenorhabditis elegans from S. aureus infection. |
128202-97-1 |
DC22107 |
HMS-101
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
1070690-06-0 |
DC6314 |
Icatibant acetate
Featured
HOE-140 (Icatibant) is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM). |
138614-30-9 |
DC9415 |
Hoechst 33342 (trihydrochloride)
Hoechst 33342 3Hcl(HOE 33342 3Hcl) is an AT-specific DNA minor groove ligand used fluorochrome for visualizing cellular DNA. |
875756-97-1 |
DC9418 |
Hoechst 33258 analog
Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA. |
258843-62-8 |
DC22129 |
HOIPIN-1(JTP-0819958;HOIP inhibitor-1)
Featured
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the N |
|
DC22108 |
HOIPIN-8
Featured
HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pa |
2519537-70-1 |
DC9650 |
Homoharringtonine
Featured
Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree. |
26833-87-4 |
DC10177 |
Homoplantaginin
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties. |
17680-84-1 |
DC5908 |
Honokiol
Featured
Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines. |
35354-74-6 |
DC12154 |
Hosenkoside A
Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
156791-82-1 |
DC12148 |
Hosenkoside B
Hosenkoside B is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
156764-82-8 |
DC12152 |
Hosenkoside F ((+)-Hosenkoside F)
Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
160896-45-7 |
DC12153 |
Hosenkoside K
Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
160896-49-1 |
DC12149 |
Hosenkoside M ((+)-Hosenkoside M)
Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
161016-51-9 |
DC23978 |
hPGDS-IN-1
Featured
hPGDS-IN-1 is a potent, selective hPGDS inhibitor with IC50 of 12 nM in FP or EIA assays.. |
1234708-04-3 |
DC23894 |
HPI-1
Featured
HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM). |
599150-20-6 |
DC12616 |
HS-152
HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC5 |
|
DC7426 |
HS-173
Featured
HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM. |
1276110-06-5 |
DC12632 |
HS220
Featured
HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 ce |
1570374-32-1 |
DC21124 |
HS-38
Featured
HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR; |
1030203-81-6 |
DC23784 |
HS-72
HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome. |
1800285-51-1 |
DC21126 |
HSD 1169
HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM). |
|
DC21125 |
HSD992
HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively. |
2222045-50-1 |
DC20064 |
HSK0935 (HSK-0935; HSK 0935)
HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities. |
1638851-44-1 |
DC12508 |
hSMG-1 inhibitor 11e
hSMG-1 inhibitor 11e is a potent, selective hSMG-1 kinase inhibitor with IC50 of <0.05 nM, >900-fold selectivity over mTOR, and no significant activity against CDK1/2.. |
1402452-10-1 |
DC12451 |
hSMG-1 inhibitor 11j
hSMG-1 inhibitor 11j is a potent, selective hSMG-1 kinase inhibitor with IC5 0of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2. |
1402452-15-6 |
DC20408 |
HSP27 inhibitor J2
HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells. |
2133499-85-9 |
DC23794 |
HSP70 modulator 115-7c
HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast. |
908074-72-6 |
DC21149 |
HT-0712
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A. |
617720-02-2 |
DC21791 |
hTG2 inhibitor VA4
hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency. |
2088001-23-2 |
DC20409 |
HTH-01-091
HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM. |
2000209-42-5 |
DC9960 |
HTHQ
Featured
HTHQ, which is a hydroquinone monoalkyl ether, is a potent anti-oxidative agent, even at low dose levels. |
148081-72-5 |
DC21128 |
HTS 01037
HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2) with Ki of 0.67 uM. |
682741-29-3 |
DC20081 |
H-Val-Pro-Pro-OH
H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. |
58872-39-2 |
DC10580 |
hVEGF-IN-1
Featured
hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity. |
1637443-98-1 |
DC20281 |
Hycanthone
Featured
Hycanthone, the most potent mutagen in a series of nine thiaxanthenones, is a potent inducer of nuclear immunoreactivity to antinucleoside antibodies in HeLa cells. |
3105-97-3 |
DCAPI1149 |
Hydralazine HCl
Hydralazine HCl |
304-20-1 |
DC20410 |
Hydrazinocurcumin
Featured
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets. |
131068-23-0 |
DCAPI1269 |
Hydrochlorothiazide
Hydrochlorothiazide |
58-93-5 |
DCAPI1198 |
Hydrocortisone (Cortisol)
Hydrocortisone (Cortisol) |
50-23-7 |
DC10227 |
Hydroquinidine
Hydroquinidine is an antiarrhythmic agent. |
1435-55-8 |
DC20277 |
Hydroxyfasudil free base
Featured
Hydroxy-Fasudil is a metabolite of Fasudil, acting as a potent Rho-kinase inhibitor and vasodilator. |
105628-72-6 |
DCAPI1226 |
Hydroxyflutamide (Hydroxyniphtholide)
Hydroxyflutamide (Hydroxyniphtholide) |
52806-53-8 |
DC10848 |
Hydroxyhexamide
Featured
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents. |
3168-01-2 |
DCAPI1045 |
Hydroxyurea (Cytodrox)
Hydroxyurea (Cytodrox) |
127-07-1 |
DCAPI1564 |
Hyoscyamine Sulfate
Hyoscyamine Sulfate |
6835-16-1 |
DC9913 |
Hypericin
Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. |
548-04-9 |
DC23001 |
Hypocrellin B
Featured
Hypocrellin B is an apoptosis inducer. The hypocrellins are pigments isolated from the fungi Hypocrella bambusae and Shiraia bambusicola. They are used as photosensitizers for photodynamic therapy of cancer. |
123940-54-5 |
DC21129 |
HZ05
HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.. |
2097360-24-0 |
DC8834 |
HZ-1157
Featured
HZ-1157 is a novel potent inhibitor of HCV NS3/4A protease; Potent Dengue virus inhibitor |
1009734-33-1 |
DC21130 |
I-191
Featured
I-191 is a novel potent, selective protease-activated receptor 2 (PAR2) antagonist with pIC50 of 7.2 in cell-based assays. |
1690172-25-8 |
DC11262 |
IACS-010759
Featured
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
1570496-34-2 |
DC12105 |
IACS-10759 Hydrochloride
IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
1807523-99-4 |
DC21131 |
IACS-4619
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM. |
1884209-98-6 |
DC21132 |
IACS-4759
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM. |
1884209-99-7 |
DC23352 |
IACS-7e
IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).. |
1800477-13-7 |
DC23361 |
IACS-9571
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
1800477-30-8 |
DC23546 |
IAXO-102
IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development. |
1115270-63-7 |
DC21905 |
IBET151-VHL-PROTAC
IBET151-VHL-PROTAC is a novel PROTAC.. |
|
DC10007 |
Ibiglustat(Genz-682452)
Featured
Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
1401090-53-6 |
DC12341 |
Ibiglustat succinate (Venglustat (succinate); GZ/SAR402671 (succinate))
Featured
Ibiglustat (succinate) is a selective inhibitor of glucosylceramide synthase. |
1629063-78-0 |
DC7635 |
IB-MECA
Featured
IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). |
152918-18-8 |
DC21134 |
IBR2
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM. |
313526-24-8 |
DC22112 |
IBS003031
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
381177-81-7 |
DC8983 |
Ibudilast
Featured
Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma,ibudilast (MN-166) is tested to treat acute respiratory distress syndrome (ARDS) associated with Covid-19. |
50847-11-5 |
DC8573 |
Ibufenac
Ibufenac is an analog of the NSAID ibuprofen that inhibits COX-1 and -2 activity with IC50 values of 17.4 and 13.1 µM, respectively. |
1553-60-2 |
DC20411 |
Ibulocydine
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
1314096-68-8 |
DC9163 |
Ibutilide fumarate
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. |
122647-32-9 |
DC21135 |
IC 86621
Featured
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM). |
404009-40-1 |
DC21136 |
IC 87361
IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β. |
404011-02-5 |
DC23271 |
IC-9564
IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain. |
174847-98-4 |
DC22114 |
ICA135
ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM. |
825601-94-3 |
DC12286 |
Icariside I
Featured
Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis. |
56725-99-6 |
DC9789 |
Icaritin(Anhydroicaritin)
Featured
Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. |
118525-40-9 |
DC9639 |
iCRT 14
Featured
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). |
677331-12-3 |
DC21139 |
iCRT-5
iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM. |
18623-44-4 |
DC20601 |
Idarubicin
Featured
Idarubicin Free Base is an orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA. |
58957-92-9 |
DC21140 |
IDD388
IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM).. |
314297-26-2 |
DC9970 |
IDE-1
Featured
IDE-1 induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). |
1160927-48-9 |
DC9971 |
IDE-2
Featured
IDE-2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). |
1136466-93-7 |
DCAPI1265 |
Idebenone
Idebenone |
58186-27-9 |
DC20068 |
IDH1 Inhibitor 1
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity. |
2234285-81-3 |
DC23637 |
IDRA-21
IDRA-21 is a positive allosteric modulator of the AMPA receptor (AMPAR). |
22503-72-6 |
DC21141 |
IDX-17119
IDX-17119 is a potent, non-nucleoside, HCV NS5B RdRp inhibitor with IC50 of 0.4 nM in replicon luciferase assay. |
1987906-92-2 |
DC21142 |
IDX-375
IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively. |
1256735-81-5 |
DC24114 |
IFNAR-IN-1
IFNAR-IN-1 is a nonpeptidic, small molecule inhibitor of IFN-α and IFNAR interaction, specifically inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 uM.. |
844882-93-5 |
DC12541 |
iGOT1-01
Featured
iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM. |
882256-55-5 |
DC11051 |
IGS-1.76
IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1). |
313480-47-6 |
DC22115 |
IHVR-19029
IHVR-19029 is a novel antiviral compound that acts as ER α-glucosidase inhibitor, synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells combined with favipiravir (T-705). |
1447464-73-4 |
DC21037 |
IIIC3
IIIC3 (Gallocyanine. |
524-26-5 |
DC21144 |
IIIM-290
IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively. |
2213468-64-3 |
DC12547 |
GDC-0214(GDC0214)
Featured
GDC0214 is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2. |
1831144-46-7 |
DC20413 |
IKK2-IN-8
IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM). |
1266240-87-2 |
DC20414 |
IKK2-IN-9
IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM). |
1266240-89-4 |
DC12631 |
IM176OUT05
Featured
IM176OUT05 is a novel, and safe small molecule that improves the acquisition and maintenance of stem cell pluripotency, inhibits electron transport chain (ETC) in the A549 lung carcinoma cell line with IC50 of 3.2 uM. |
1544871-16-0 |
DC23593 |
Imagabalin
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
610300-07-7 |
DC23565 |
Imagabalin hydrochloride
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
610300-00-0 |
DC9242 |
Imatinib(free base)
Featured
Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. |
152459-95-5 |
DC8678 |
Imazapic
Imazapic is a selective herbicide for both the preand post-emergent control of some annual and perennial grasses and some broadleaf weeds |
104098-48-8 |
DC20415 |
Imazaquin
Imazaquin is an imidazolinone herbicide that effectively controls a broad spectrum of weed species, by inhibiting acetohydroxy acid synthase (AHAS).. |
81335-37-7 |
DC23259 |
IMB-301
IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). |
64009-84-3 |
DC23731 |
iMDK
iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF. |
881970-80-5 |
DC8890 |
Imidafenacin
Featured
Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). |
170105-16-5 |
DC20211 |
Imidazole;1,3-diazole; glyoxaline; 1,3-diazacyclopenta-2,4-diene
Imidazole is a heterocyclic aromatic organic compound. It can be incorporated into many important biological molecules and acts as a corrosion inhibitor for industrial applications. |
288-32-4 |
DC22092 |
Imidazole ketone erastin(IKE)
Featured
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. |
1801530-11-9 |
DC20207 |
Imidazole-4(5)-acetic Acid Hydrochloride
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. |
3251-69-2 |
DC21292 |
Imipenem
Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.. |
64221-86-9 |
DC8988 |
Imiquimod
Featured
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
99011-02-6 |
DC10406 |
Imisopasem manganese
Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD. |
218791-21-0 |
DC21145 |
IMM-01
IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM. |
218795-74-5 |
DC21146 |
IMM-02
IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM. |
218929-99-8 |
DC10027 |
Importazole
Featured
Importazole is an inhibitor of importin-β transport receptors. |
662163-81-7 |
DC8874 |
7-TACA
Impurity D of Cefoperazone |
37539-03-0 |
DC12578 |
IMTPPE
Featured
IMTPPE (SID3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells. |
851688-13-6 |
DC8450 |
(R)-Equol
In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively. |
221054-79-1 |
DC23397 |
INCB054329
INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency. |
1628607-64-6 |
DC20176 |
INCB057643
Featured
INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. |
1820889-23-3 |
DC26025 |
INCB086550(INCB-086550)
Featured
INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. |
2230911-59-6 |
DC21497 |
INCB10820
INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively. |
1310796-72-5 |
DC11311 |
Incensole
Incensole is a diterpene originally isolated from frankincense produced by B. carterii.It inhibits degradation of inhibitor of NF-κB (IκBα) in a concentration-dependent manner in TNF-α-stimulated HeLa cells when used at concentrations ranging from 60 to 1 |
22419-74-5 |
DCAPI1136 |
Indapamide (Lozol)
Indapamide (Lozol) |
26807-65-8 |
DC21246 |
Indimitecan
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor.. |
915360-05-3 |
DC8906 |
Indinavir
Featured
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. |
150378-17-9 |
DC8838 |
Indirubin
Featured
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. |
479-41-4 |
DC20984 |
Indisulam
Featured
Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
165668-41-7 |
DC23921 |
Indolactam V
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively. |
90365-57-4 |
DCAPI1311 |
Indole-3-carbinol
Featured
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). |
700-06-1 |
DCAPI1237 |
Indomethacin (Indocid, Indocin)
Indomethacin (Indocid, Indocin) |
53-86-1 |
DC9568 |
Indoprofen
Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. |
31842-01-0 |
DC20276 |
Indotecan(LMP400)
Featured
Indotecan(LMP400) is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity. |
915303-09-2 |
DC21138 |
Inflachromene
Featured
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. |
908568-01-4 |
DC9651 |
Ingenol 3-angelate
Featured
Ingenol 3-Angelate is a PKC(protein kinase C)activator; anti-cancer drug and an active ingredient in Euphorbia peplus. |
75567-37-2 |
DC9653 |
Ingenol 5,20-Acetonide
Ingenol 5,20-Acetonide (CAS 77573-43-4) |
77573-43-4 |
DC9654 |
Ingenol 5,20-Acetonide-3-O-angelate
Ingenol 5,20-Acetonide-3-O-angelate (CAS 87980-68-5) |
87980-68-5 |
DC9646 |
Ingenol
Featured
Ingenol is an extremely weak protein kinase C (PKC) activator. |
30220-46-3 |
DC9652 |
Ingenol-3,4:5,20-diacetonide
Ingenol-3,4:5,20-diacetonide (CAS 77573-44-5) |
77573-44-5 |
DC22212 |
RNF5 INHIBITOR INH-02
Featured
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1. |
324579-65-9 |
DC7640 |
INH1
INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
313553-47-8 |
DC21704 |
Inh2-B1
Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain. |
690216-38-7 |
DC7479 |
Tiplaxtinin(PAI-039)
Featured
Inhibitor of plasminogen activator inhibitor-1 (PAI-1) |
393105-53-8 |
DCAPI1453 |
IBANDRONATE SODIUM
Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's. |
138926-19-9 |