Cat. No. | Product name | CAS No. |
DCAPI1578 |
Irsogladine maleate
Irsogladine maleate is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. It is a potent inhibitor of angiogenesis in wild-type and plasminogen activator-deficient mice. |
84504-69-8 |
DC3158 |
Milrinone
Featured
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE |
78415-72-2 |
DC9579 |
Nortadalafil
Featured
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. IC50 value: Ta |
171596-36-4 |
DC9583 |
Oglemilast
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma. |
778576-62-8 |
DC9577 |
Olprinone (Hydrochloride)
Featured
Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
119615-63-3 |
DC10345 |
PDE1-IN-2
PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. |
1904611-63-7 |
DC11367 |
PF-04447943
Featured
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC10418 |
PF-04957325
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B. |
1305115-80-3 |
DC11937 |
PF 05180999
Featured
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
1394033-54-5 |
DC7201 |
PF-2545920(MP-10)
Featured
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
898562-94-2 |
DC7247 |
PF-8380
Featured
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM. |
1144035-53-9 |
DC4146 |
Roflumilast
Featured
Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM. |
162401-32-3 |
DC11671 |
RPL-554
RPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively. |
298680-25-8 |
DC8048 |
SEP-0372814
Featured
SEP-0372814 is a potent PDE10 inhibitor. |
1516895-53-6 |
DC9779 |
Sildenafil citrate
Featured
Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. |
171599-83-0 |
DC7298 |
MY-5445
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM). |
78351-75-4 |
DC5901 |
Tadalafil
Featured
Tadalafil is a potent and selective inhibitor of Phosphodiesterase-5 (PDE5) This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can |
171596-29-5 |
DC7945 |
TAK-063
Featured
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. |
1238697-26-1 |
DC11661 |
BAY 73-6691
BAY 73-6691 is a drug developed by Bayer for the treatment of Alzheimer's disease. It was the first compound developed that acts as a phosphodiesterase inhibitor selective for the PDE9A subtype. |
794568-92-6 |
DC4133 |
Udenafil
Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED) |
268203-93-6 |
DC9182 |
Vardenafil hydrochloride trihydrate
Featured
Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. |
330808-88-3 |
DC9847 |
Vesnarinone(OPC8212)
Featured
Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. |
81840-15-5 |