Deltarasin |CAS 1440898-61-2|DC Chemicals

Cas No.:	1440898-61-2
Chemical Name:	Deltarasin
Synonyms:	Deltarasin;1H-Benzimidazole, 2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-;C40H37N5O;BCP20971;2363AH;BDBM50019865;s7224;SB19574;SW219816-1;A13722;1-benzyl-2-{4-[(2S)-2-(2-phenyl-1H-1,3-benzodiazol-1-yl)-2-(piperidin-4-yl)ethoxy]phenyl}-1H-1,3-benzodiazole
SMILES:	O(C1C([H])=C([H])C(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])=C([H])C=1[H])C([H])([H])[C@]([H])(C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N1C(C2C([H])=C([H])C([H])=C([H])C=2[H])=NC2=C([H])C([H])=C([H])C([H])=C12
Formula:	C₄₀H₃₇N₅O
M.Wt:	603.7547
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Deltarasin is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction(Kd= 41 nM. binding to PDEδ) and impairs oncogenic KRAS signalling.Interfering with binding of mammalian PDEδ to KRAS by means of small molecules provides a novel opportunity to suppress oncogenic RAS signalling by altering its localization to endomembranes. Biochemical screening and subsequent structure-based hit optimization yielded inhibitors of the KRAS-PDEδ interaction that selectively bind to the prenyl-binding pocket of PDEδ with nanomolar affinity, inhibit oncogenic RAS signalling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. For the detailed information of Deltarasin, the solubility of Deltarasin in water, the solubility of Deltarasin in DMSO, the solubility of Deltarasin in PBS buffer, the animal experiment (test) of Deltarasin, the cell expriment (test) of Deltarasin, the in vivo, in vitro and clinical trial test of Deltarasin, the EC50, IC50,and affinity,of Deltarasin, For the detailed information of Deltarasin, the solubility of Deltarasin in water, the solubility of Deltarasin in DMSO, the solubility of Deltarasin in PBS buffer, the animal experiment (test) of Deltarasin, the cell expriment (test) of Deltarasin, the in vivo, in vitro and clinical trial test of Deltarasin, the EC50, IC50,and affinity,of Deltarasin, Please contact DC Chemicals.

MSDS

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2018-0101

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