| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC41342 | Ayanin | Ayanin is a bioflavonoid isolated from Croton schiedeanus Schlecht. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for the study of respiratory disease,such as allergic asthma et al. |
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| DC41379 | Ilexsaponin B2 | Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC50 values of 48.8 μM and 477.5 μM, respectively. |
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| DC41489 | Kushenol B | Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 μM. |
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| DC42340 | Autotaxin modulator 1 | Autotaxin modulator 1 is an autotaxin (ATX) enzyme, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer. |
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| DC42341 | LY-411575 (isomer 3) | LY-411575 isomer 3 is an isomer of LY411575, which is a potent γ-secretase. |
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| DC42521 | MBCQ Featured | MBCQ is a potent and selective the type V phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ has IC50s >100 µM for PDE1, PDE2, PDE3, and PDE4, respectively. MBCQ dilates coronary arteries via potent and specific inhibition of cGMP-PDE. |
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| DC44761 | Vardenafil hydrochloride | Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively. |
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| DC45449 | (+)-Medioresinol Di-O-β-D-glucopyranoside | (+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity of 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase. |
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| DC46127 | Sildenafil-d3 | Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. |
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| DC46173 | FR-229934 | FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1. FR-229934 can be used for the research of pulmonary arterial hypertension and erectile dysfunction. |
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| DC46253 | LASSBio-1632 | LASSBio-1632 is a new anti-asthmatic lead candidate associated with selective inhibition of PDE4A and PDE4D isoenzymes and blockade of airway hyper-reactivity (AHR) and TNF-α production in the lung tissue. LASSBio-1632 (7j) displays high experimental BBB permeability across BBB through passive diffusion. |
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| DC46402 | Tovinontrine | Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively. |
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| DC46435 | PF-8380 hydrochloride | PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. |
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| DC46873 | Senazodan hydrochloride | Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III. |
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| DC46874 | Carbazeran citrate | Carbazeran (citrate), a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran (citrate) can be used for the research of metabolic disease. |
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| DC47087 | Orismilast | Orismilast (LEO-32731) is a PDE4 inhibitor used for the research of inflammatory diseases. |
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| DC47201 | Irsenontrine | Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE 9) inhibitor. Irsenontrine can be used for the research of neurological diseases. |
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| DC47223 | Ro 20-1724 | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect. |
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| DC47386 | N-Desmethyl Sildenafil | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. |
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| DC47387 | PDE4-IN-3 | PDE4-IN-3 is a novel and orally active PDE4 inhibitor with potent inhibitory affinity (IC50 = 4.2 nM). |
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| DC47882 | TMX-4113 | TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer. |
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| DC47883 | TMX-4100 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma. |
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| DC47925 | PDE4-IN-4 | PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled treatment of pulmonary diseases. |
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| DC47989 | FPFT-2216 Featured | FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease. |
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| DC48220 | Mufemilast | Mufemilast is a phosphodiesterase 4 (PDE4) inhibitor. |
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| DC48221 | Andolast | Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM. |
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| DC48222 | Arofylline | Arofylline is a PDE4 inhibitor as a potential treatment for asthma. |
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| DC48223 | ATX inhibitor 7 | ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure. |
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| DC48224 | Cudetaxestat | Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor. |
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| DC48225 | PDE2A-IN-1 | PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 value of 1.3 nM. |
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