| DC67174 |
TK-129
Featured
|
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease. |
|
| DC67175 |
ATX968
Featured
|
ATX968 (example 31) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the EC50 of 0.054 μM in circBRIP1. ATX968 has antitumor activity. |
|
| DC67176 |
N-(2-methylpropyl)decanamide
Featured
|
|
|
| DC67177 |
BTK-IN-29
Featured
|
BTK-IN-29 (compound 14) is an inhibitor of Btk. |
|
| DC67178 |
(E/Z)-DMU2139
Featured
|
(E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139 (HY-101285). (E/Z)-DMU2139 is a potent and specific CYP1B1 inhibitor (IC50: 4 nM). |
|
| DC67179 |
Bavisant dihydrochloride
Featured
|
Bavisant (JNJ-31001074) dihydrochloride is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research. |
|
| DC67180 |
Trimedoxime (TMB-4)
Featured
|
Trimedoxime (TMB-4) is a potent reactivator of AChE. Trimedoxime shows potency in inducing oxidative stress, with the IC50 of 22 mM. |
|
| DC67181 |
Sulfaperin
Featured
|
Sulfaperin (Methylsulfadiazin) is an antibacterial agent. |
|
| DC67182 |
AHL modulator-1
Featured
|
AHL modulator-1 (compound 12) is a modulator of N-acylated L-homoserine lactone (AHL), with the agonism and antagonism of 21% and 42% in cellulase activity and 5% and 32% in potato macerationa, respectively. |
|
| DC67183 |
UM4118
Featured
|
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research. |
|
| DC67184 |
BBT
Featured
|
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway. |
|
| DC67185 |
EF24 HCl
Featured
|
EF24 HCl is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. |
|
| DC67186 |
Sulfaethoxypyridazine
Featured
|
Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs. |
|
| DC67187 |
Aromatase-IN-2
Featured
|
Aromatase-IN-2 is a potent aromatase inhibitor with an IC50 value of 1.5 µM. |
|
| DC67188 |
GPR183-IN-2
Featured
|
GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca2+ mobilization with an IC50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis. |
|
| DC67189 |
OGT-IN-1
Featured
|
OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC50s of 27 and 10 μM, respectively. |
|
| DC67190 |
A3AR antagonist 5
Featured
|
A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM. |
|
| DC67191 |
Zacopride
Featured
|
Zacopride is a selective agonist with the activity of enhancing the inward rectifier potassium current (IK1) in rabbit hearts. Zacopride also exhibits significant antiarrhythmic effects, inhibiting ventricular arrhythmias by increasing IK1 without affecting atrial arrhythmias. Zacopride can hyperpolarize the resting membrane potential and shorten the action potential duration (APD) in a concentration-dependent manner. Zacopride significantly reduced the incidence of compound-induced early afterdepolarizations (EADs) at 1 μmol/L. |
|
| DC67192 |
3-(4-isopropylbenzylidene)indolin-2-one
Featured
|
|
|
| DC60707 |
YTHDC1 inhibitor 40 (compound 40)
Featured
|
YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM. Compound 40 shows antiproliferative activity against the acute myeloid leukemia (AML) cell lines THP-1, MOLM-13, and NOMO-1.YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively. YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML. |
.jpg)
|
| DC60708 |
KAI-11101
Featured
|
KAI-11101 is a potent, selective, brain-penetrant DLK inhibitor with Ki of 0.7 nM. KAI-11101 also demonstrates favorable preclinical PK, including good CNS penetration, and in vitro safety profiles. |
|
| DC67193 |
N-(3S)-3-Piperidinyl-2-thiophenesulfonamide
Featured
|
|
|
| DC67194 |
(5-pyrrolidin-1-ylsulfonyl-2-furyl)methanamine
Featured
|
|
|
| DC67195 |
N-(2-aminoethyl)-5-chlorothiophene-2-sulfonamide
Featured
|
|
|
| DC67196 |
phenyl 2,5-Dichloro-3-Thienyl Sulfone
Featured
|
|
|
| A817 |
Zolbetuximab
Featured
|
Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors. |
|
| A818 |
DS-9606A
Featured
|
DS-9606A is a humanized antibody expressed in CHO cells, targeting CLDN6. DS-9606A features an IgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.84 kDa. The isotype control for DS-9606A can refer to Human IgG1 kappa, Isotype Control (HY-P99001). |
|
| A819 |
Anti-CLDN6 Reference Antibody (64A)
Featured
|
|
|
| A820 |
Anti-CLDN6 Antibody (AB3-7)
Featured
|
|
|
| A821 |
Anti-CLDN6 Reference Antibody (AE3-20)
Featured
|
|
|
