| DC67224 |
3D-Monophosphoryl Lipid (14)
Featured
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3D-Monophosphoryl Lipid (14) (3D-MPL (14)) is a biochemical reagent. |
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| DC67225 |
3D-MPL(12;16)
Featured
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3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines[1]. |
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| DC67226 |
3D-MPLA
Featured
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3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) is a TLR agonist that can be used as an adjuvant for vaccines to enhance their immunogenicity. |
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| DC67227 |
UM-3006
Featured
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UM-3006 is a highly efficient TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. UM-3006 holds significant research and application potential in the fields of vaccine adjuvants and immune diseases. |
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| DC67228 |
DSPE-PEG-Folate
Featured
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DSPE-PEG-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research. |
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| DC67229 |
DSPE-PEG-Mannose
Featured
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DSPE-PEG-Mannose,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethyleneglycol)-Mannose (sodium salt)is white solid for drug delivery systems, It is an active target material, Itcan be used as an antitumor drug carrier and active targeted delivery |
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| DC67230 |
AYK005
Featured
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AYK005 is a TLR7/8 immunologic adjuvant. |
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| DC67231 |
AYK004
Featured
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AYK004 is a TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. AYK004 is an adenine derivative with a favorable hydrophilic-lipophilic balance, which improves the loading capacity and stability in immunoadjuvant systems such as liposomes, while reducing the side effects of the immunoadjuvant system in systemic immunity . |
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| DC67232 |
AYK004-B1
Featured
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AYK004-B1 is a TLR7 agonist (EC50=0.2265 nM). AYK004-B1 can be used to prepare immune adjuvants. |
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| DC67233 |
AYK004-C1
Featured
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AYK004-C1 is a TLR agonist. AYK004-C1 can be used to prepare immune adjuvants. |
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| DC67234 |
CPG-1018
Featured
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| DC67235 |
CPG 7909
Featured
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| DC67236 |
QS-7
Featured
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QS 7 (QS 7 Api) is a saponin compound that can be extracted from the Quillaja saponaria tree. QS 7 activates immune cells, enhances their antigen presentation ability and cytokine secretion. QS 7 can be used as vaccine adjuvant for immunostimulating, anti-tumor, and anti-infectious activities. |
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| DC67237 |
TQL-1055
Featured
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TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21 (HY-101092) and can be used as a prophylactic vaccine adjuvant. TQL-1055 exhibits robust adjuvant activity for influenza antigens. TQL-1055 combined with the acellular pertussis vaccine (aP) shows good tolerance and enhances the antibody response to pertussis toxin (PT) in mice and rabbits. TQL-1055 is promising for research of chronic hepatitis B. |
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| DC67238 |
KRN-7000(C34)
Featured
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| DC67239 |
KRN-7000(S34)
Featured
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| DC67240 |
KRN-7000(7DW8-5)
Featured
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| DC67274 |
Cp2-S04
Featured
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Cp2-SO4 is a phenylalanine derivative that acts as an inhibitor of interleukin-4-induced-1 (IL4I1), an enzyme implicated in immune regulation and tumor immune evasion. IL4I1 is an L-amino acid oxidase that promotes an immunosuppressive microenvironment by producing metabolites like H2O2 and kynurenine, which inhibit T-cell proliferation and function. Cp2-SO4 reverses IL4I1-dependent suppression of T-cell proliferation, making it a promising candidate for cancer immunotherapy and immune-related diseases. Its Ki value of 21.2 µM indicates its potency in blocking IL4I1 activity. |
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| DC74630 |
Antiviral agent 17 |
Antiviral agent 17 is an anti-infection agent. |
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| DC74631 |
JAK-IN-21 |
JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor. |
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| DC74632 |
Dimethylamiloride |
Dimethylamiloride is a Na(+)-H+ exchange inhibitor. |
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| DC74633 |
TCMDC-137332 |
TCMDC-137332 is a compound that exhibits antimalarial activity against Plasmodium falciparum with an IC50 value of 7 nM. |
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| DC74634 |
Seladelpar free acid |
Seladelpar, also known as MBX-8025 and RWJ-800025, is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. MBX-8025 may have potential use for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
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| DC74635 |
ATH434 mesylate |
ATH434, also known as PBT434, is a novel, brain-penetrant, inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin. |
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| DC74636 |
Bromo-PADAP |
Bromo-PADAP is a dye agent for research use. Bromo-PADAP was reported for the spectrophotometric determination of uranium(VI). Bromo-PADAP is highly sensitive towards uranium, the uranyl complex having a molar absorptivity of 74,000 at 578 nm and pH 7.6. In the presence of a mixed masking solution only a few ions interfere seriously, and the method can be made specific for uranium by a preliminary extraction of uranium into tri-n-octylphosphine oxide, and direct development of the bromo-PADAP colour in the organic phase. Details are given for the determination of uranium in waters, ores, phosphoric acid and phosphate rocks, thorium oxide, and zirconium oxide. |
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| DC74637 |
Deuremidevir free base |
Deuremidevir, also known as VV116, JT001, and mindeudesivir, is a chemically-modified version of the antiviral remdesivir with oral bioavailability and potent activity against SARS-CoV-2. VV116 is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects. VV116 showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model. Note: the non-labeled analog is called GS621763 (Cat#465727). |
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| DC74638 |
GLPG3667
Featured
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GLPG3667 is an oral, reversible, and selective tyrosine kinase 2 (TYK2) inhibitor. It is being developed to treat inflammatory and auto-immune diseases. Biochemical assays showed that GLPG3667 displayed nanomolar potency on TYK2 with a selectivity over other JAK kinases >3-fold. In human PBMC, GLPG3667 showed comparable potency on the IFNα and IL-23 pathways (around 50 nM). Selectivity for TYK2 on the IFNα pathway was >14-fold and >19-fold toward the IL-2 and GM-CSF pathways in human PBMC and whole blood, respectively. Dermal ear inflammation in a mouse model of psoriasis driven by IL-23 was prevented by GLPG3667 with a minimal effective dose of 3 mg/kg given orally once daily. This effect was associated with a decrease in neutrophil infiltration and STAT3 phosphorylation at sites of inflammation. In healthy HV, GLPG3667 completely inhibited IFNα-induced STAT1 and STAT3 phosphorylation but did not impact IL-2- and GM-CSF-induced STAT5 phosphorylation. |
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| DC74639 |
Oligopeptide-10
Featured
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Oligopeptide-10, also known as granactive oligopeptide-10, is a synthetic bio-active peptide composed of 15 amino acids. it can help manage acne-causing bacteria, both on its own and in conjunction with anti-acne superstar exfoliant salicylic acid. |
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| DC74641 |
HC-258
Featured
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HC-258 is a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells. Co-crystallization with hTEAD2 confirmed that HC-258 binds within TEAD’s PA pocket, where it forms a covalent bond with its cysteine. |
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| DC74642 |
Mtb ATP synthase-IN-1 |
Mtb ATP synthase-IN-1 is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. |
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