| DC67360 |
GSPT1 degrader-4
Featured
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GSPT1 degrader-4 (compound 3) functions as a potent molecular glue targeting GSPT1, demonstrating a degradation concentration (DC50) of 25.4 nM. The compound exhibits strong anti-proliferative activity in CAL51 cells with an IC50 value of 39 nM. |
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| DC67361 |
IKZF-IN-1
Featured
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IKZF-IN-1 (Compound I) is a molecular glue degrader that selectively targets IKZF1/2/3/4 (Ikaros zinc finger family proteins) for proteasomal degradation. This immunomodulatory compound holds therapeutic potential for investigating cancer and viral infection treatment strategies. |
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| DC67362 |
QXG-6442
Featured
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QXG-6442 is a potent molecular glue degrader targeting CK1α, demonstrating high degradation efficiency (DC50 = 5.7 nM, Dmax = 90%). This compound significantly suppresses proliferation in the MOLM-14 leukemia cell line, highlighting its therapeutic potential. |
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| DC67363 |
Antitumor agent-100 hydrochloride
Featured
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Antitumor agent-100 (compound A6) hydrochloride is an orally bioavailable molecular glue that selectively targets the PDE3A-SLFN12 complex (IC50 = 0.3 μM). By binding to the PDE3A catalytic pocket, it stabilizes SLFN12 interaction, subsequently inhibiting protein translation and triggering apoptotic cell death. This dual mechanism underlies its potent antitumor activity. |
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| DC67364 |
dCK1α-2
Featured
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dCK1α-2 is an orally bioavailable molecular glue degrader targeting CK1α, a key regulator of p53 pathway signaling. This compound demonstrates robust in vivo anti-tumor activity in murine models while upregulating expression of p53-associated genes, highlighting its dual mechanism of action. |
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| DC67365 |
3-Indoleacetic acid-d4
Featured
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3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is a deuterium-stabilized isotopologue of the endogenous auxin phytohormone 3-indoleacetic acid (HY-18569). As the predominant natural auxin, 3-IAA regulates fundamental plant growth processes, including cellular elongation and proliferation, when supplemented in plant tissue culture systems. |
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| DC67366 |
KT-333 ammonium
Featured
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KT-333 ammonium (Compound A) is a targeted molecular glue degrader that induces STAT3 protein degradation via the ubiquitin-proteasome pathway. The compound facilitates this process by simultaneously engaging both STAT3 and the VHL E3 ubiquitin ligase, demonstrating remarkable degradation selectivity. With potent antitumor efficacy, KT-333 ammonium shows particular promise for investigating therapeutic interventions in hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL). |
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| DC67367 |
Lenalidomide-13C5,15N
Featured
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Lenalidomide-13C5,15N is an isotopically labeled analog of lenalidomide (HY-A0003; CC-5013), a thalidomide-derived molecular glue compound. This orally bioavailable immunomodulator functions through selective cereblon (CRBN) E3 ubiquitin ligase engagement, mediating targeted ubiquitination and proteasomal degradation of lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 complex. The compound demonstrates dual therapeutic activity by both suppressing proliferation of mature B-cell malignancies (including multiple myeloma) and enhancing T-cell immunostimulation through IL-2 induction. |
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| DC67368 |
rac-Lenalidomide-13C5
Featured
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rac-Lenalidomide-13C5 is a carbon-13 labeled racemic variant of lenalidomide, designed for tracer studies in pharmacokinetic and metabolic research. |
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| DC67369 |
AR Degrader-2
Featured
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AR Degrader-2 (Compound 2) is a molecular glue compound that induces targeted degradation of the androgen receptor (AR), demonstrating potent activity with a DC50 ranging from 0.3 to 0.5 μM in VCaP prostate cancer cells. |
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| DC67370 |
BRD9 Degrader-2
Featured
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BRD9 Degrader-2 (Compound B11) is a highly potent and efficient molecular degrader of BRD9, achieving sub-nanomolar degradation activity (DC50 ≤1.25 nM) with maximal degradation exceeding 75%. This compound represents a promising chemical tool for investigating BRD9-dependent oncogenic pathways in cancer research. |
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| DC67371 |
ChREBPα/14-3-3 regulator-1
Featured
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ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the ChREBP/14-3-3 protein complex with an EC50 of 3.8 μM. By enhancing this interaction, the compound demonstrates cytoprotective effects against glucolipotoxicity in pancreatic β cells while preserving cellular function. These properties position it as a promising investigational tool for type 2 diabetes research. |
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| DC67372 |
3-Indoleacetic acid (standard)
Featured
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3-Indoleacetic acid (Standard) serves as an analytically validated reference material for the phytohormone indole-3-acetic acid (IAA). Designed for precision research applications, this auxin-class plant growth regulator modulates fundamental developmental processes including cellular expansion, tissue differentiation, and organ morphogenesis, driving vegetative growth in plant systems. |
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| DC67373 |
BRD4 degrader-2
Featured
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BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue that orchestrates targeted BRD4 degradation through ternary complex formation with the E3 ligase RNF126. This compound selectively engages both BRD4 isoforms (long and short) for proteasomal elimination, demonstrating pan-isoform degradation capability in cellular systems. |
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| DC67374 |
AR Degrader-1
Featured
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AR Degrader-1 (Compound ML 2-9) is a monovalent molecular glue that selectively targets the androgen receptor (AR) for degradation via recruitment of the DCAF16 E3 ubiquitin ligase. Demonstrating a favorable safety profile, this compound effectively degrades AR in LNCaP prostate cancer cells without inducing significant cytotoxicity. |
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| DC67375 |
IKZF3 degrader 1
Featured
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IKZF3 degrader 1 (compound 19a) is a potent molecular glue that induces targeted IKZF3 degradation (EC50 = 12 nM) by facilitating its recruitment to the cereblon (CRBN) E3 ubiquitin ligase complex. This enforced protein-protein interaction triggers subsequent ubiquitination and proteasomal elimination of IKZF3. |
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| DC67376 |
GSPT1 degrader-1
Featured
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GSPT1 degrader-1 (compound 9q) is a potent molecular glue that mediates targeted degradation of G1-to-S phase transition protein 1 (GSPT1) through the ubiquitin-proteasome pathway. This compound exhibits dual biological activity by inducing cell cycle arrest at the G0/G1 phase checkpoint and triggering apoptotic signaling cascades. |
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| DC67377 |
JP-2-249
Featured
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JP-2-249 functions as a molecular glue degrader that selectively targets SMARCA2 for proteasomal degradation. In MV-4-11 leukemia cells, treatment with JP-2-249 (1–10 μM) induces dose-dependent reduction of SMARCA2 protein levels, demonstrating potent degradation activity. |
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| DC67378 |
GSPT1 degrader-2
Featured
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GSPT1 degrader-2 (Compound 210) is an orally bioavailable molecular glue that achieves potent, sub-30 nM degradation of GSPT1 (DC50 < 30 nM), demonstrating robust antitumor efficacy in preclinical models. |
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| DC67379 |
STING Degrader-1
Featured
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STING Degrader-1 (compound 2) is a covalent molecular glue that simultaneously engages STING and its cognate E3 ligase, inducing targeted protein degradation. The compound exhibits a characteristic hook effect, achieving maximal STING depletion (75%) at 10 μM, while higher concentrations (30 μM) show reduced degradation efficiency (~30%). |
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| DC67380 |
CQ627
Featured
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CQ627 is a targeted molecular glue that promotes RIOK2 degradation through the ubiquitin-proteasome pathway by bridging interactions between RIOK2 and the E3 ligase RNF126, achieving a DC50 of 410 nM in MOLT4 leukemia cells. This compound demonstrates multi-modal anticancer activity, including: (1) dose-dependent apoptosis induction, (2) G2/M phase cell cycle arrest, and (3) broad-spectrum antiproliferative effects across cancer cell lines. Furthermore, CQ627 shows significant in vivo efficacy in MOLT4 xenograft models, validating its therapeutic potential. |
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| DC67381 |
Z-NCTS
Featured
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Z-NCTS is a sequence-selective RNA-binding molecule that specifically targets 5’-r(XGG)-3’/5’-r(XGG)-3’ mismatches (where X = U or A), functioning as a molecular glue to stabilize these RNA duplex structures. |
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| DC67382 |
IKZF1-degrader-2
Featured
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IKZF1-degrader-2 (Compound 3) is a targeted molecular glue that induces selective degradation of IKZF1, demonstrating potent anticancer efficacy with an advantageous safety profile. |
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| DC67383 |
UNC8732
Featured
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UNC8732 is a dual-functional compound that both inhibits and degrades NSD2, offering a two-pronged approach to targeting this epigenetic regulator. |
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| DC67384 |
CDK4 degrader 1
Featured
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CDK4 degrader 1 (ML 1–71) is a molecular glue compound that selectively induces cyclin-dependent kinase 4 (CDK4) degradation through targeted ubiquitin-proteasome system recruitment. |
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| DC67385 |
BRD9 Degrader-3
Featured
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BRD9 Degrader-3 (compound B20) is a highly potent molecular glue that induces targeted BRD9 degradation, demonstrating exceptional activity with a DC50 below 1.25 nM. |
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| DC67386 |
UNC8732 TFA
Featured
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UNC8732 (TFA salt) is a bifunctional agent that simultaneously inhibits NSD2 methyltransferase activity and promotes its targeted degradation, offering dual epigenetic modulation. |
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| DC67387 |
XYD049
Featured
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XYD049 (compound 7d) is a CRBN-recruiting molecular glue that selectively degrades GSPT1 with high potency (DC50 = 19 nM), demonstrating therapeutic potential against MYC-driven castration-resistant prostate cancer (CRPC). |
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| DC67388 |
GR–14-3-3 stabilizer-1
Featured
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GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue designed to reinforce the glucocorticoid receptor (GR)-14-3-3 protein interaction. By selectively stabilizing this complex, it effectively disrupts GR signaling and serves as a versatile scaffold for developing targeted molecular glues. |
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| DC67389 |
GSPT1 degrader-6
Featured
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GSPT1 degrader-6 (compound 8) is a highly potent molecular glue that induces targeted degradation of GSPT1, demonstrating exceptional activity with a DC50 of 13 nM. |
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