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Cat. No. Product Name Field of Application Chemical Structure
DC67372 3-Indoleacetic acid (standard) Featured 3-Indoleacetic acid (Standard) serves as an analytically validated reference material for the phytohormone indole-3-acetic acid (IAA). Designed for precision research applications, this auxin-class plant growth regulator modulates fundamental developmental processes including cellular expansion, tissue differentiation, and organ morphogenesis, driving vegetative growth in plant systems.
DC67373 BRD4 degrader-2 Featured BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue that orchestrates targeted BRD4 degradation through ternary complex formation with the E3 ligase RNF126. This compound selectively engages both BRD4 isoforms (long and short) for proteasomal elimination, demonstrating pan-isoform degradation capability in cellular systems.
DC67374 AR Degrader-1 Featured AR Degrader-1 (Compound ML 2-9) is a monovalent molecular glue that selectively targets the androgen receptor (AR) for degradation via recruitment of the DCAF16 E3 ubiquitin ligase. Demonstrating a favorable safety profile, this compound effectively degrades AR in LNCaP prostate cancer cells without inducing significant cytotoxicity.
DC67375 IKZF3 degrader 1 Featured IKZF3 degrader 1 (compound 19a) is a potent molecular glue that induces targeted IKZF3 degradation (EC50 = 12 nM) by facilitating its recruitment to the cereblon (CRBN) E3 ubiquitin ligase complex. This enforced protein-protein interaction triggers subsequent ubiquitination and proteasomal elimination of IKZF3.
DC67376 GSPT1 degrader-1 Featured GSPT1 degrader-1 (compound 9q) is a potent molecular glue that mediates targeted degradation of G1-to-S phase transition protein 1 (GSPT1) through the ubiquitin-proteasome pathway. This compound exhibits dual biological activity by inducing cell cycle arrest at the G0/G1 phase checkpoint and triggering apoptotic signaling cascades.
DC67377 JP-2-249 Featured JP-2-249 functions as a molecular glue degrader that selectively targets SMARCA2 for proteasomal degradation. In MV-4-11 leukemia cells, treatment with JP-2-249 (1–10 μM) induces dose-dependent reduction of SMARCA2 protein levels, demonstrating potent degradation activity.
DC67378 GSPT1 degrader-2 Featured GSPT1 degrader-2 (Compound 210) is an orally bioavailable molecular glue that achieves potent, sub-30 nM degradation of GSPT1 (DC50 < 30 nM), demonstrating robust antitumor efficacy in preclinical models.
DC67379 STING Degrader-1 Featured STING Degrader-1 (compound 2) is a covalent molecular glue that simultaneously engages STING and its cognate E3 ligase, inducing targeted protein degradation. The compound exhibits a characteristic hook effect, achieving maximal STING depletion (75%) at 10 μM, while higher concentrations (30 μM) show reduced degradation efficiency (~30%).
DC67380 CQ627 Featured CQ627 is a targeted molecular glue that promotes RIOK2 degradation through the ubiquitin-proteasome pathway by bridging interactions between RIOK2 and the E3 ligase RNF126, achieving a DC50 of 410 nM in MOLT4 leukemia cells. This compound demonstrates multi-modal anticancer activity, including: (1) dose-dependent apoptosis induction, (2) G2/M phase cell cycle arrest, and (3) broad-spectrum antiproliferative effects across cancer cell lines. Furthermore, CQ627 shows significant in vivo efficacy in MOLT4 xenograft models, validating its therapeutic potential.
DC67381 Z-NCTS Featured Z-NCTS is a sequence-selective RNA-binding molecule that specifically targets 5’-r(XGG)-3’/5’-r(XGG)-3’ mismatches (where X = U or A), functioning as a molecular glue to stabilize these RNA duplex structures.
DC67382 IKZF1-degrader-2 Featured IKZF1-degrader-2 (Compound 3) is a targeted molecular glue that induces selective degradation of IKZF1, demonstrating potent anticancer efficacy with an advantageous safety profile.
DC67383 UNC8732 Featured UNC8732 is a dual-functional compound that both inhibits and degrades NSD2, offering a two-pronged approach to targeting this epigenetic regulator.
DC67384 CDK4 degrader 1 Featured CDK4 degrader 1 (ML 1–71) is a molecular glue compound that selectively induces cyclin-dependent kinase 4 (CDK4) degradation through targeted ubiquitin-proteasome system recruitment.
DC67385 BRD9 Degrader-3 Featured BRD9 Degrader-3 (compound B20) is a highly potent molecular glue that induces targeted BRD9 degradation, demonstrating exceptional activity with a DC50 below 1.25 nM.
DC67386 UNC8732 TFA Featured UNC8732 (TFA salt) is a bifunctional agent that simultaneously inhibits NSD2 methyltransferase activity and promotes its targeted degradation, offering dual epigenetic modulation.
DC67387 XYD049 Featured XYD049 (compound 7d) is a CRBN-recruiting molecular glue that selectively degrades GSPT1 with high potency (DC50 = 19 nM), demonstrating therapeutic potential against MYC-driven castration-resistant prostate cancer (CRPC).
DC67388 GR–14-3-3 stabilizer-1 Featured GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue designed to reinforce the glucocorticoid receptor (GR)-14-3-3 protein interaction. By selectively stabilizing this complex, it effectively disrupts GR signaling and serves as a versatile scaffold for developing targeted molecular glues.
DC67389 GSPT1 degrader-6 Featured GSPT1 degrader-6 (compound 8) is a highly potent molecular glue that induces targeted degradation of GSPT1, demonstrating exceptional activity with a DC50 of 13 nM.
DC67390 Pan-RAS-IN-5 Featured Pan-RAS-IN-5 (compound 7A) is a molecular glue that induces a functional ternary complex between cyclophilin A (CYPA) and activated RAS (RAS-ON), effectively disrupting RAF recruitment and downstream signaling. This unique mechanism translates to potent anti-tumor activity.
DC67391 WIZ degrader 8 Featured WIZ degrader 8 (compound 10) is a potent and selective molecular glue that induces targeted degradation of the transcription factor WIZ, resulting in robust upregulation of fetal hemoglobin (HbF) expression. This dual activity—WIZ depletion coupled with HbF induction—positions it as a promising therapeutic candidate for sickle cell disease.
DC67392 PROTAC GSPT1 degrader-2 Featured PROTAC GSPT1 degrader-2 (compound A) is a highly efficient molecular glue that achieves near-complete GSPT1 degradation (>95%). This compound demonstrates potent anti-proliferative activity in HL-60 leukemia cells, with an IC50 value of 10 nM, highlighting its therapeutic potential.
DC67393 Pomalidomide-d5 Featured Pomalidomide-d5 is a deuterium-stabilized isotopologue of pomalidomide, a third-generation immunomodulatory drug that functions as a molecular glue degrader. This compound mediates targeted protein degradation by recruiting the cereblon E3 ubiquitin ligase to promote ubiquitination and proteasomal elimination of Ikaros family transcription factors (IKZF1/3), a mechanism central to its therapeutic activity.
DC67394 HGC652 Featured HGC652 is a first-in-class molecular glue that selectively recruits the E3 ubiquitin ligase TRIM21 to form a ternary complex with NUP98, triggering targeted degradation of NUP155 and nuclear pore complex (NPC) proteins. This unique mechanism induces potent cytotoxicity across multiple cancer types, with activity correlating with cellular TRIM21 expression levels.
DC67395 Cyclosporin A-d3 Featured Cyclosporin A-d3 is a deuterium-enriched isotopologue of Cyclosporin A (HY-B0579), designed for metabolic stability studies and quantitative mass spectrometry applications.
DC67396 CDK-IN-9 Featured CDK-IN-9 (compound 24) is a bifunctional agent that combines potent CDK2/E inhibition (IC50 = 4 nM) with molecular glue activity, selectively bridging CDK12 and DDB1 to trigger polyubiquitination and proteasomal degradation of cyclin K.
DC67397 JWJ-01-306 Featured JWJ-01-306 is a first-in-class molecular glue that selectively targets and degrades the C2H2 zinc finger transcription factor ZBTB11, disrupting mitochondrial metabolism by suppressing oxidative phosphorylation (OXPHOS) and the tricarboxylic acid (TCA) cycle. This dual metabolic reprogramming activity overcomes proliferation in KAS-mutant pancreatic ductal adenocarcinoma (PDAC) cells while demonstrating favorable pharmacokinetic properties in vivo.
DC67398 SJ46411-Br Featured SJ46411-Br is a selective CRL2^KLHDC2 E3 ligase ligand that facilitates cooperative, target-specific ternary complex formation. Its modular design enables conjugation to BET inhibitors like JQ1 (HY-13030) via PROTAC linkers, serving as a versatile scaffold for developing KLHDC2-directed degraders.
DC67399 VAV1 degrader-2 Featured VAV1 degrader-2 (Example 176) is a high-potency molecular glue that selectively targets VAV1 for degradation (DC50 = 4.41 nM), demonstrating therapeutic potential for modulating inflammatory and autoimmune pathways.
DC67400 ER degrader 9 Featured ER degrader 9 (compound 1) is a bifunctional molecular glue that achieves sub-10 nM degradation potency (DC50 ≤10 nM) against estrogen receptor (ER) in MCF-7 breast cancer cells, demonstrating significant potential for therapeutic development in ER-dependent malignancies.
DC67401 GSPT1 degrader-5 Featured GSPT1 degrader-5 (compound 4) is a molecular glue compound that induces targeted degradation of GSPT1 with a DC50 of 144 nM, demonstrating moderate but selective activity.

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