DC23501 |
Finazine |
Finazine is a high-affinity, brain penetrant sigma-1 and sigma 2 receptor ligand with Ki of 2.6 nM and 46 nM, respectively. |
|
DC12637 |
Finerenone
Featured
|
Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease. |
|
DC8936 |
Fingolimod |
Fingolimod(FTY720 free base) is a S1P antagonist with IC50 of 0.033 nM. |
|
DC11309 |
Fipronil |
Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 and 1,600 nM for cockroach and rat receptors, respectively). |
|
DC8200 |
Firategrast(SB-683699)
Featured
|
Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). |
|
DC8917 |
Firocoxib |
Firocoxib(ML 1785713) is a potent and selective cyclooxygenase (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity for COX2 VSCOX1. |
|
DC21015 |
FIT-039
Featured
|
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM). |
|
DC9845 |
FITM
Featured
|
FITM is a nove mGlu1 inhibitor. FITM shows high affinity (Ki = 2.5 nM, fig. S2) and selectivity for mGlu1 over mGlu5. |
|
DC20386 |
Pioglitazone
Featured
|
Pioglitazone is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. |
|
DC21016 |
FJ 5002 |
FJ 5002 is a potent telomerase inhibitor with IC50 of 2 uM, a close derivative of MKT077. |
|
DC7112 |
FK 3311
Featured
|
FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent. |
|
DC22093 |
FKGK18 |
FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM. |
|
DC10845 |
FL-411
Featured
|
FL-411 is a selective BRD4 inhibitor. |
|
DC20019 |
Flagelin 22(TFA) (Flagellin 22(TFA)) |
Flagelin 22 TFA, a fragment of bacterial flagellin, is an effective elicitor in both plants and algae. |
|
DC10972 |
Flavokawain B |
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression. |
|
DC2014 |
Flavopiridol
Featured
|
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM. |
|
DC8780 |
Flavopiridol Hydrochloride
Featured
|
Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. |
|
DC11414 |
Flavoxate Hydrochloride
Featured
|
Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic. |
|
DC9623 |
Flecainide (acetate)
Featured
|
Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
|
|
DCAPI1347 |
Fleroxacin (Quinodis) |
Fleroxacin (Quinodis) |
|
DC7415 |
FLI-06
Featured
|
FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM). |
|
DC9321 |
Flibanserin
Featured
|
Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.
|
|
DC8726 |
FLLL31
Featured
|
FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway. |
|
DC7751 |
FLLL32
Featured
|
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. |
|
DC8164 |
Gilteritinib(ASP2215)
Featured
|
FLT3/AXL inhibitor |
|
DC8230 |
FLT3-IN-1(SKLB4771)
Featured
|
FLT3-IN-1(SKLB4771) is a novel potent and selective Flt3 inhibitor with IC50 of 10 nM; against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM. |
|
DC11780 |
FLT3-IN-5e |
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM. |
|
DC9060 |
Flubendazole |
Flubendazole is a potent broad spectrum anthelmintic. |
|
DCAPI1375 |
Fluconazole |
Fluconazole |
|
DCAPI1108 |
Flucytosine (Ancobon) |
Flucytosine (5-Fluorocytosine, 5-FC, Ancobon) is an antifungal drug with IC50 of 0.12 μg/mL in C.albicans. |
|