| DC23114 |
R788 disodium hexahydrate
Featured
|
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
|
| DC12315 |
Fosteabine (Cytarabine ocfosfate; YNK 01) |
Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase. |
|
| DC23893 |
Foxy-5(Wnt5a peptide mimetic)
Featured
|
Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility. |
|
| DC10510 |
FPH1 (BRD-6125)
Featured
|
FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes. |
|
| DC10947 |
FPL64176
Featured
|
FPL64176 is a potent L-type Ca++ channel activator with EC50 of 16 nM. |
|
| DC8720 |
FPS-ZM1
Featured
|
FPS-ZM1 is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively. |
|
| DC21023 |
FQI1 |
FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 2.1 uM. |
|
| DC21024 |
FQI2 |
FQI2 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.71 uM. |
|
| DC21025 |
FR900098 sodium salt
Featured
|
FR 900098 is a derivative of fosmidomycin that inhibits DOXP reductoisomerase, demonstrates antimalarial activity with IC50 of 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively.. |
|
| DC12242 |
FR194738 |
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. |
|
| DC12398 |
FR58P1a |
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. |
|
| DC23729 |
FR-901464
Featured
|
FR-901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.. |
|
| DC8631 |
Framycetin sulphate |
Framycetin sulphate |
|
| DC9887 |
FRAX1036
Featured
|
FRAX1036 is a novel ATP-competitive small molecule inhibitor of group I p21-activated Kinases (PAKs). |
|
| DC8003 |
FRAX-486
Featured
|
FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM). |
|
| DC8154 |
FRAX 597
Featured
|
FRAX597 is a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. |
|
| DCQ-033 |
fraxin |
Fraxin is a coumarin glycoside that has been found in Fraxinus and has anti-inflammatory activity. |
|
| DC23050 |
fraxinellone
Featured
|
Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities. |
|
| DC9344 |
Frentizole |
Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.
|
|
| DC20208 |
Frovatriptan Succinate |
Frovatriptan Succinate is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors. |
|
| DC7902 |
Fruquintinib (HMPL-013)
Featured
|
Fruquintinib (HMPL-013) is a novel small molecule compound that selectively inhibits vascular endothelial growth factor receptors (VEGFRs). |
|
| DC21026 |
FSC 231 |
FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM. |
|
| DC23388 |
FT-001 |
FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1. |
|
| DC20272 |
FT113
Featured
|
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. |
|
| DC11554 |
FT-671
Featured
|
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). |
|
| DC22096 |
FT895 |
FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM). |
|
| DC11029 |
FTBMT
Featured
|
FTBMT is a novel selective GPR52 agonist of GPR52, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively. |
|
| DC8421 |
FTI 277 HCl
Featured
|
FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. |
|
| DC12537 |
FtsZ inhibitor C109 |
FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM. |
|
| DC3154 |
Fingolimod HCl（FTY-720）
Featured
|
FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
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