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Cat. No. Product name CAS No.
DC73821 SLU-PP-915

SLU-PP-915 is a potent pan-ERR (Estrogen-related receptor) nuclear receptor agonist with EC50 of 414/435/378 nM for ERRα/ERRβ/ERRγ, respectively.

2285432-92-8
DC73822 SMIP34

SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions.

946262-80-2
DC73823 X15695

X15695 is a potent, selective and orally active estrogen receptor alpha (ERα) degrader, destabilizes ERα and stabilizes p53, inhibits ER+ breast cancer cell growth.

353258-25-0
DC73824 eEF2K degrader C1

eEF2K degrader C1 is a small-molecule degrader of eEF2K, acts a molecular glue to enhance the interaction of eEF2K with the ubiquitin E3 ligase βTRCP, thereby promoting the proteasomal degradation of eEF2K.

1044797-96-7
DC73825 MG-002

MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM.

2768406-34-2
DC73826 RBF197

RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM.

848930-88-1
DC73827 SBI-0498

SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.

931789-29-6
DC73828 SBI-5844

SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.

832680-32-7
DC73829 HPG1860

HPG1860 is a potent, selective, nonbile acid full FXR agonist with EC50 of 5 nM and 18 nM in FR-FRET and luciferase assays, respectively.

2226133-29-3
DC73830 ID166

ID119031166 (ID166) is a novel potent, selective FXR agonist with EC50 of 3 nM and 5 nM in TR-FRET FXR co-activator assay and FXR reporter assay, respectively.

2247972-61-6
DC73831 MET409

MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR).

2244500-76-1
DC73832 PDL103

PDL103 is a potent, dual FXR/GPBAR1 antagonist with IC50 of 10 and 19 uM, respectively.

DC73833 3i-1262

3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.

DC73834 ER-400583-00

ER-400583-00 is a small-molecule HIF-1α inhibitor, inhibits the induction of HIF-1 reporter activity in response to hypoxia with IC50 of 7.9 nM.

1338216-76-4
DC73835 FG-0041

FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.

53946-49-9
DC73836 MO-2097

MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.

2744300-63-6
DC73837 D-F07

D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells.

2361297-58-5
DC73838 PAIR1

PAIR1 is a partial antagonist of IRE1α RNase (PAIR) that fully engage IRE1α's kinase domain (Ki=220 nM) but only partially inhibit its RNase activity.

2771006-58-5
DC73839 TC-D-F07

TC-D-F07 is a novel prodrug of the covalent IRE-1 inhibitor D-F07, inhibits IRE-1/XBP-1s pathway in cancer cells.

2378311-45-4
DC73840 BC-1901S

BC-1901S is a potent small molecule NRF2 activator that stabilizes NRF2 and increases NRF2 activity, activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner.

1358617-36-3
DC73841 S217879

S217879 (S 217879) is a highly potent and selective NRF2 activator, binds to KEAP1 Kelch domain (SPR Kd=4.15 nM), disrupts the KEAP1-NRF2 interaction leading to robust NRF2 pathway activation.

DC73842 sAKZ692

sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase.

950430-20-3
DC73843 NC114

NC114 is a small molecule targeting cancer-associated KLF5 transcription factor, decreases the KLF protein but not mRNA levels of KLF in vitro.

2768328-96-5
DC73844 4A7C-301

4A7C-301 is a potent, selective, brain-penetrant agonist of nuclear receptor Nurr1 with EC50 of 6.53 uM, binds to Nurr1 ligand binding domain (LBD) with IC50 of 50 nM.

DC73845 BRF110

BRF110 is a potent, selective, brain penetrant and vivo active agonist of Nurr1-RXRα heterodimers with EC50 of 900 nM.

2095489-35-1
DC73846 SA00025

SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1.

1015231-98-7
DC73847 XCT0135908

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.

300837-31-4
DC73848 MBX-102 acid

MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overla

23953-39-1
DC73849 MMT-160

MMT-160 is a novel selective peroxisome proliferator-activated receptor γ (PPARγ) antagonist with IC50 of 0.17 uM, covalently binds to the PPARγ ligand binding domain (LBD) via Cys285.

1639059-34-9
DC73850 SR10221

SR10221 is a potent, selective PPARγ inverse agonist with IC50 of 13 nM in biochemical peptide recruitment assays, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

1415321-64-0
DC73851 FKK6

FKK6 (Felix Kopp Kortagere 6) is a specific human pregnane X receptor (hPXR) agonist with IC50 of 1.56 uM in a cell-free competitive hPXR TR-FRET-binding assays.

2238839-34-2
DC73852 SJPYT-318

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.

DC73853 AG-205

A small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.

442656-02-2
DC73854 AGN196996

AGN 196996 (IRX6696) is a potent selective RARα antagonist with Ki of 2 nM, shows little to no activity against RARβ and RARγ.

958295-17-5
DC73855 BPA-B9 Featured

BPA-B9 (Bipyridine amide B9) is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=39 nM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.

DC73856 CD666

CD666 is a potent, selective RARgamma (RARγ) agonist.

144006-45-1
DC73857 E6060

E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.

196518-98-6
DC73858 IRX4647

IRX4647 is a selective RARγ agonist, regulates T cell biology and reduces syngeneic tumor growth of immune checkpoint-resistant lung cancer cell line (344SQ) when combined with anti-PD-L1.

DC73859 LG101506

LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.

331248-11-4
DC73860 XS-060

XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.

2787626-06-4
DC73861 STL1267

STL1267 is a specific, high affinity synthetic agonist of nuclear receptor REV-ERB with EC50 of 0.13 uM and Ki of 0.16 uM, binds directly to the ligand binding domain (LBD) of REV-ERB.

1429024-58-7
DC73862 BMS-336

BMS-336 is a potent, selective, orally active RORγt (RORC2) inverse agonist with EC50 of 39 nM in RORγt reporter assays.

2204226-97-9
DC73863 ODH-08

ODH-08 is a novel specific small molecule ligand and agonist of RORα with KD value of 8.4 um, shows potent antifibrotic effect.

2924984-09-6
DC73864 PCCR-1

PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.

1820667-82-0
DC73865 W6134

W6134 (RORγ covalent inhibitor 29) is a first-in-class, potent and selective RORγ covalent inhibitor with IC50 of 0.21 uM, targets the Cys320 of RORγ.

2983540-55-0
DC73866 CS27109 Featured

CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.

2556627-24-6
DC73867 EN171 Featured

EN171 covalently targets both C38 and C96 on 14−3−3 to enhance 14−3−3 interactions with ERα, YAP, and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity.

2191110-79-7
DC73868 CNB-001

CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.

1019110-87-2
DC73869 DDQ

DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects.

2660017-53-6
DC73870 MeSC-04

MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro.

DC73871 NPT200-11

NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.

1802518-63-3
DC73872 SRI-42667

SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.

3024624-72-1
DC73873 CC-8977

CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.

DC73874 SMP-114

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.

215174-50-8
DC73875 BMS-332

BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.

2407892-15-1
DC73876 BMS-684

BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.

313552-29-3
DC73877 JNJ-3790339

JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin.

93076-87-0
DC73878 GRL018-21

GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.

DC73879 (3S) ALG-05

(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.

DC73880 (R)-HTS-3

(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.

DC73881 (R)-SKBG-1 Featured

(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.

2955634-67-8
DC73882 (S)-CKi-1 Featured

(S)-CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.6 uM, depletes creatine phosphagen energetics in cells.

2768295-41-4
DC73883 (S)-IBD3540

(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models.

2676156-11-7
DC73884 2,5-pyridinedicarboxylic acid

2,5-pyridinedicarboxylic acid is a highly selective D-dopachrome tautomerase (D-DT, MIF2) inhibitor with Ki of 17.2 uM, 79-fold selectivity over MIF, effectively blocks the D-DT-induced activation of CD74.

100-26-5
DC73885 2-TCPA

2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.

2136639-04-6
DC73886 3-mercaptopicolinic acid hydrochloride

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK, PCK) inhibitor with Ki of 2-9 uM, an inhibitor of gluconeogenesis.

320386-54-7
DC73887 4BPPNit

4BPPNit is a small molecule significantly augmented glycosylation of α-dystroglycan, in part through upregulation of LARGE1 glycosyltransferase gene expression.

197569-89-4
DC73888 4-Sulfocalix[6]arene hydrate

4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.

102088-39-1
DC73889 4-Sulfocalix[8]arene hydrate

4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.

137407-62-6
DC73890 5M-8OH-Q Featured

5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.

312611-90-8
DC73891 7-Fluorotryptamine

7-fluorotryptamine (7FTA) is a potent synthetic agonist of GPRC5A with EC50 of 7.2 uM for inducing GPRC5A-mediated β-arrestin recruitment.

191927-74-9
DC73892 7-Fluorotryptamine hydrochloride

7-fluorotryptamine (7FTA) is a potent synthetic agonist of GPRC5A with EC50 of 7.2 uM for inducing GPRC5A-mediated β-arrestin recruitment.

159730-09-3
DC73893 AD-5584

AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.

2306525-79-9
DC73894 AD-8007

AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.

1497439-74-3
DC73895 AE 51310

AE 51310 is a small-molecule inhibitor of Opsin 4/melanopsin (OPN4), has antitumor potential in patient-derived xenograft (PDX) tumors in mice..

433966-92-8
DC73897 AGF347

AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM).

2294820-23-6
DC73898 AGI-25696 Featured

AGI-25696 (AGI 25696) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A, blocks the growth of MTAP-deleted tumors in vivo.

2201066-35-3
DC73899 AK-3280

AK-3280 (AK 3280, GDC 3280, RG 6069) is an orally available, potential novel anti-fibrotic small molecule under investigation for the treatment of interstitial lung diseases.

1799412-33-1
DC73900 AKST1220

AKST1220 is a potent, specific leukotriene A4 hydrolase (LTA4H) inhibitor, improves hippocampal dependent memory.

1400796-48-6
DC73901 Alrefimotide

Alrefimotide (Telomerase reverse transcriptase 660-689 peptide antigen).

DC73902 AM9053 (AM 9053)

AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM).

157469-21-1
DC73903 Antabactin

Antabactin (ANT) is a highly potent pan-abscisic acid (ABA) receptor antagonist with EC50 of 760 nM and picomolar dissociation constant, disrupts signaling by preventing receptor-PP2C interactions.

2570821-88-2
DC73904 AP736

AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.

1365531-21-0
DC73905 APC655

APC655 is a potent activator of protein folding and unfolded protein response (UPR) modulator, APC655 activates ATF6 pathway and chaperone expression.

385786-31-2
DC73906 AQIM-I

AQIM-I is a highly potent small molecule survivin inhibitor by targeting ILF3/NF110, binds to ILF3/NF110 with KD value of 163 nM in SPR assays, has broad-spectrum antitumor activity.

2247881-73-6
DC73907 ARL67156

ARL67156 (FPL 67156) is a selective inhibitor of ecto-ATPase, ARL67156 is a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively.

160928-38-1
DC73908 ART899

ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558.

2607139-85-3
DC73909 ARUK2001607 Featured

ARUK2001607 is a potent, selective and brain penetrant PI5P4Kγ inhibitor with binding KD of 7.1 nM, pIC50 of 7.1 (PI5P4Kγ+).

2924824-56-4
DC73910 ARUK200282

ARUK200282 is a potent, isoform-selective PI5P4Kα inhibitor with pIC50 of 8.0, selective over PI5P4Kβ and PI5P4Kγ.

DC73911 ARUK2002821

ARUK2002821 is a potent, selective PI5P4Kα inhibitor with pIC50 of 8.0, >1000-fold selective over PI5P4Kγ.

DC73912 ARUK2007145

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.

DC73913 ASB17061

ASB17061 (ASB-17061) is an orally active, selective chymase inhibitor with IC50 of 0.03 uM and 0.02 uM for mMCP-4 and human chymase, respecitvely.

1312993-33-1
DC73914 ASN 90

ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.

1884154-02-2
DC73915 ASP7967

ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM.

1246834-49-0
DC73916 AZ13792138

AZ13792138 is a highly potent, selective inhibitor of MTH1 (NUDT1) with Kd/IC50 of 0.4/0.5 nM.

DC73917 BCL3ANT

BCL3ANT (NSC-659509) is a small molecule inhibitor of Bcl-3-mediated cyclin D1 expression, reduces cyclin D1 luciferase activity in Bcl-3-overexpressing melanoma cells with IC50 of 40.4 uM.

910855-84-4
DC73918 BD442618

BD442618 (BD 442618) is a potent small-molecule GPR52 agonist.

DC73919 BD50265

BD50265 (BD 50265) is a potent small-molecule GPR52 agonist.

DC73920 BI-0955

BI-0955 is an inactive HSD17B13 control compound for BI-3231.

DC73921 BI-9466

BI-9466 (BI 9466) is the negative control of NSD3-PWWP1 domain chemical probe BI-9321.

2538293-52-4
DC73922 BiTud

BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibit

2758663-98-6
DC73923 BK697

BK697 is a small molecule targeting FIRΔexon2, potentially interacts with FIRΔexon2, significantly suppresses the FIRΔexon2 expression and inhibits tumor cell growth and several rRNA expressions.

1839048-73-5
DC73924 BNZ-1

BNZ-1 (BNZ132-1-40) is a pegylated peptide, BNZ132-1 conjugated with methoxy-PEG40 maleimide molecule via a specific linker (CGSGG), specifically binds the γc receptor to selectively block IL-2, IL-15 and IL-9 signaling.

DC73925 BNZ132-1

BNZ132-1 (QITISILSQINRVFHEKFI) is a specific peptide inhibitor for the IL-2/IL-15 subfamily, directly binds to the γc molecule (CD132).

DC73926 BR102910

BR102910 (BR 102910) is a novel potent, selective, oral fibroblast activation protein (FAP) inhibitor with IC50 of 1 nM.

2505339-54-6
DC73927 BRD4780

BRD4780 is a small molecule that releases MUC1-fs from TMED9-enriched compartments and promotes its anterograde trafficking to the lysosome, directly binds to TMED9.

2568912-84-3
DC73928 BRD8518

BRD8518 is a specific small molecule TRIB1 inducer, modulates expression of the key genes involved in VLDL production and in LDL clearance in HepG2 cells.

1565828-01-4
DC73929 BRM011

BRM011 (dual BRM and BRG1 inhibitor 11) is a potent, selective, allosteric dual BRM and BRG1 inhibitor with IC50 of <5 nM for both.

2270875-79-9
DC73930 Butaselen

Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines.

857375-83-8
DC73931 C105SR

C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling.

DC73932 C10M

C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.

2824243-53-8
DC73933 C902 Featured

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.

1395472-39-5
DC73934 Calmirasone1

Calmirasone1 (Calmirasone 1) is a novel and potent covalent calmodulin (CaM) inhibitor with Kd of 0.87 uM.

DC73935 CARD8 activator CQ31

CARD8 activator CQ31 is a small molecule that selectively activates CARD8.

441022-67-9
DC73936 CASK chemical probe 18

CASK chemical probe 18 is a highly potent and selective CASK inhibitor with IC50 of 22 nM.

2755241-73-5
DC73937 CB253

CB253 is a small molecule that selectively binds the hairpin form of r(G4C2)exp, inhibiting mechanisms that drive c9ALS/FTD pathobiology.

1225169-17-4
DC73938 CBK034026C

CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity.

DC73939 CBLC000

CBLC000 (CBL0100) is a small molecule histone chaperone FACT inhibitor, activates p53 and inhibits NF-κB with EC50 of 0.06 and 0.03 uM in cell-based p53 and NF-κB reporter assays, respecitvely.

1197996-83-0
DC73940 CC-410

CC-410 (CC410) is a potent, specific inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 1.6 uM (human NNMT).

636564-27-7
DC73941 CHD1Li 11

CHD1Li 11 (CHD1L inhibitor 11) is a small molecule inhibitor of chromodomain helicase DNA-binding protein 1 like (CHD1L) with IC50 of 4.57 uM.

1015582-93-0
DC73942 CIB-3b

CIB-3b is a small molecule inhibitor disrupting the TRBP-Dicer interaction, suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.

124811-87-6
DC73943 Cimlanod

Cimlanod is a second-generation nitroxyl (HNO) donor..

1620330-72-4
DC73944 CK147

CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.

1883356-12-4
DC73945 CKi-4

Creatine kinase inhibitor CKi-4 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.3 uM, depletes creatine phosphagen energetics in cells.

2768295-28-7
DC73946 CKi-6

CKi-6 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.6 uM, depletes creatine phosphagen energetics in cells.

2768295-15-2
DC73947 Cl-NIO

Cl-NIO is a potent, selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 1.3 uM, > 500-fold selectivity against arginase and endothelial nitric oxide synthase.

1606129-72-9
DC73948 CMP05 Featured

CMP05 (Endosomolytic compound CMP05) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.

DC73949 CMP05-7

CMP05-7 (Endosomolytic compound CMP05-7) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.

1905413-00-4
DC73950 CNS-11

CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.

445218-34-8
DC73951 CNS-11g

CNS-11g is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.

1309162-57-9
DC73952 Coproporphyrin III

Coproporphyrin III is a diffusible small molecule porphyrin excreted by human-associated Propionibacterium spp., induces Staphylococcus aureus aggregation and biofilm formation, also induces S. aureus to form a plasma-independent surface-attached biofilm.

14643-66-4
DC73953 CPAG-1 Featured

CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2. CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels. CPAG-1 decreased Rev-Erbα protein in BAT of CPAG-1-treated mice. CPAG-1 also significantly increased labile heme in the nucleus of brown adipocytes from CPAG-1-treated mice within 4 days of treatment.

2094991-62-3
DC73954 CPR1-B

CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).

2819664-58-7
DC73955 CQ211

CQ211 is a potent, highly selective RIOK2 inhibitor with Kd of 6.1 nM, shows excellent selectivity to RIOK2 in both enzymatic and cellular assays.

2648986-65-4
DC73956 CRS0540

CRS0540 is a potent, selective PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes.

DC73957 CT-179

CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization.

1996636-69-1
DC73958 CU-76

CU-76 (cGAS inhibitor CU-76) is a small-molecule human cGAS (hcGAS) inhibitor with IC50 of 0.24 uM.

2400954-58-5
DC73959 CW3388

CW3388 (CW-3388, CW3388) is a potent, cell-active Δ8,7-sterol isomerase (EBP) inhibitor, shows near-maximal effects on oligodendrocyte formation at 110 nM.

414881-01-9
DC73960 CW4142

CW4142 (CW 4142) is a small molecule SC4MOL inhibitor that enhances oligodendrocyte formation.

150199-99-8
DC73961 CW5107

CW5107 (CW 5107) is a small molecule HSD17B7 inhibitor that enhances oligodendrocyte formation.

DC73962 Cytochalasin B

Cytochalasin B is a cell-permeable mycotoxin that inhibits network formation by actin filaments, inhibits cell movement and induces nuclear extrusion.

14930-96-2
DC73963 DB2313 Featured

DB2313 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 29 nM.

2170606-74-1
DC73964 DC-SX029

DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.

300713-88-6
DC73965 DDIT

DDIT is a potent, non-toxic inhibitor of hyaluronan synthesis via targeting hyaluronan synthase (HAS), significantly suppresses the aggressiveness of triple-negative breast cancer cells grown in tissue culture.

869355-30-6
DC73966 DDX3X helicase 64

DDX3X helicase 64 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 0.14 μM, shows promising anti-HCV activity, with an EC50 of 0.2 μM and cytotoxicity of 86 μM.

DC73967 DDX3X helicase 79

DDX3X helicase 79 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 5 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 1.6 and 2.3 uM, respectively.

2414591-16-3
DC73968 DDX3X helicase 86

DDX3X helicase 87 is a potent, selective and aller inhibitor of DDX3X helicase activity with IC50 of 7 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 6.3 and 0.88 uM, respectively.

2571070-57-8
DC73969 DFO-5

DFO-5 (Oseltamivir Epoxy Impurity) is an oseltamivir impurity.

204254-96-6
DC73970 DFTD

DFTD is a time-dependent, reversible and covalent inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K) targeting of Cys-146, DFTD binds to the ATP binding site of eEF-2K.

208254-22-2
DC73971 DHAB

DHAB is a potent, specific small molecule inhibitor of kidney ADPR-cyclase with IC50 of 2.5 nM, does not inhibit CD38, spleen, heart or brain ADPR-cyclase activity in vitro.

51437-66-2
DC73972 DHC-156

DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.

DC73973 Dibutepinephrine

Dibutepinephrine is a sympathomimetic compound.

2735735-23-4
DC73974 Dichloroallyl lawsone

Dichloroallyl lawsone (Dichlorolapachol, DCL, NSC-126771) is a synthetic analogue of the antimalarial lapachol, inhibits mitochondrial dihydroorotate dehydrogenase (DHODH) with antineoplastic activity.

36417-16-0
DC73975 Dihydrorhodamine 123

Dihydrorhodamine 123 (DHR 123) is a cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite..

109244-58-8
DC73976 DiI

Dil (DiIC18(3)) is a fluorescent neuronal tracer that labels cell bodies, axons, dendrites, and dendritic spines.

DC73977 DKC1125

DKC1125 is a small molecule KSRP-binding compound that specifically inhibits the oncogenic KITENIN complex, suppresses distant metastasis of colorectal cancer (CRC).

DC73978 DS07551382

DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.

2488609-68-1
DC73979 DS21150768

DS21150768 is a potent selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with IC50 of 3.27 nM in cell-free HPK1 assays, binds to HPK1 with an affinity constant (KD) of 6.08 nM.

DC73980 DS55980254 Featured

DS55980254 (DS 55980254) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1) inhibitor, suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.

2488609-41-0
DC73981 DS68591889

DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.

2488609-21-6
DC73982 DSHN-OMe

DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.

DC73983 DSK638

DSK638 (DSK-638) is a potent small moelcule RECK inducer, binds histone deacetylases (HDACs) with IC50 of 5-10 uM for HDAC1/3.

71255-53-3
DC73984 DSRM-3716

DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM, displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).

58142-99-7
DC73985 Ederimotide

Ederimotide (WT1-A1) is a synthetic peptide derived from nonamer sequences of the Wilms tumor protein 1 (WT1), increases human T-cell responses and shows potential as cancer vaccine.

852243-39-1
DC73986 EML417

EML417 is a small molecule that selectively interactes with the Tudor domain of PHF20.

2101956-23-2
DC73987 Endosidin17

Endosidin17 (ES17) is a small molecule targets retromer component VPS35, binds to VPS35 Impairs interaction with RABG3f, causes dose-dependent stabilization of VPS35 with EC50 of 0.9 uM.

433261-83-7
DC73988 EP055

EP055 (EP-055) is a small molecule that targets EPPIN on the surface of sperm and inhibits motility (IC50=199.5 uM, CASA assay using human sperm), binds to the C-terminal domain of EPPIN.

2411173-40-3
DC73989 EPIC-0412

EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.

DC73990 Equilin

Equilin (7-Dehydroestrone) is a highly potent 3βHSD1 inhibitor with IC50 of 2.8 nM in VCaP cells, also inhibits the activity of purified 3βHSD1 with SPR KD of 2.23 uM.

474-86-2
DC73991 Ethanimidothioic acid

Ethanimidothioic acid (R5421) is an inhibitor of platelet scramblase activity.

81862-15-9
DC73992 EVT-701

EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM.

1918948-94-3
DC73993 F12511

Eflucimibe (F 12511) is a highly potent, selective inhibitor of acyl-CoA: cholesterol acyltransferase ( ACAT/SOAT) with IC50 of 3, 7, and 71 nM in whole cell assays using HepG2, CaCo-2 and THP-1 cell lines, respectively.

202340-45-2
DC73994 F759

F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

2649904-85-6
DC73995 F83236

F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

DC73996 FDW028

FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.

2768426-49-7
DC73997 Feeblin

Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.

689270-18-6
DC73998 FK3453

FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo.

560111-91-3
DC73999 FMP-201300

FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.

312922-93-3
DC74000 GCN2iA

GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM.

2287180-43-0
DC74001 GE1111

GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM.

DC74002 GMFBI.1

GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.

709608-85-5
DC74003 GNE-1858

GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 with IC50 of 1.9 nM in the SLP76 phosphorylation assay.

2680616-96-8
DC74004 GNF362

GNF362 (GNF-362) is a highly potent, selective inhibitor of inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) with IC50 of 9 nM.

1003019-41-7
DC74005 GNF-9228

GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation.

313234-20-7
DC74006 GO-203

GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling.

1222186-26-6
DC74007 GQ352

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.

DC74008 GSK898

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.

1953156-92-7
DC74009 H3B-616

H3B-616 (H3B 616) is a potent, selective allosteric inhibitor of CPS1 with IC50 of 66 nM, demonstrates no appreciable inhibition of CPS2 (IC50>100 uM).

2468199-06-4
DC74010 HB-MIX1902 Supplement (10X)

HB-MIX1902 Supplement (10X) is an optimized serum-free supplement used to promote and maintain the growth, maturity and viability of iPS-derived hepatic and biliary cells. MIX1902 is provided as a 10X liquid and is intended to be used with Hepatocyte Cult

DC74011 HJ445A

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.

DC74012 HP661

HP661 is a potent, and selective oral complex I OXPHOS inhibitor with 76% inhibition at 1u M in H460 cells using electron flow assays, inhibits high-OXPHOS H460 cell viability with IC50 of 5 nM.

2938220-60-9
DC74013 HPK1 PROTAC SS44

HPK1 PROTAC SS44 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.

2636072-58-5
DC74014 HQY426

HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.

DC74015 HQY436

HQY436 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.15 uM, exhibits potent antitumor activity.

DC74016 HsClpP activator ZK53

HsClpP activator ZK53 is a potent, selective activator of mitochondrial caseinolytic protease P (HsClpP) with EC50 of 0.22 uM in FI-based protease activity assays, inactive toward bacterial ClpP proteins.

DC74017 HTL0041178

HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52).

2642079-89-6
DC74018 HTS13286

HTS13286 is a selective AQP9 inhibitor with IC50 of 1.5 uM (inhibition of CHO-AQP9 cell water permeability).

727359-12-8
DC74019 HYGIC

HYGIC is a small molecule that simultaneously induces hypocotyl elongation and thickening via the ethylene signaling pathway activated by endogenous ethylene.

923742-91-0
DC74020 I194496

I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.

445238-07-3
DC74021 IBS007125

IBS007125 is a small molecule inhibitor of c-Maf, inhibits multiple myeloma proliferation by targeting cMaf transcriptional activity.

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