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Cat. No. Product Name Field of Application Chemical Structure
DC10936 GSK3179106 Featured GSK3179106 (GSK-3179106, GSK 3179106) is a potent, selective, first-in-class and gut-restricted with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively.
DC10647 EPZ015938(pemrametostat) Featured GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor.
DC7143 GSK-343 Featured GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases.
DC8505 GSK369796 Featured GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain
DC1035 GSK3787 Featured GSK3787 is as a potent and selective antagonist of PPARδ with pIC50 of 6.6.
DC8648 GSK4112 Featured GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
DC7144 GSK429286A Featured GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
DC22306 cGAS inhibitor 467 Featured GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1). GSK467 exploits unique binding modes.
DC8589 PAD4 inhibitor GSK484 Featured GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme.
DC8044 GSK503 Featured GSK503 is a specific EZH2 methyltransferase inhibitor.
DC12513 RIP1 inhibitor GSK547 Featured GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo.
DC9733 GSK583 Featured GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM).
DC10391 EBI2 inhibitor GS682753A GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
DC9831 GSK6853 Featured GSK6853 is a potent, soluble, cell active, and highly selective inhibitor of the BRPF1 bromodomain
DC2070 GSK690693 Featured GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.
DC8373 GSK8573 Featured GSK-8573 is the inactive control of GSK-2801.
DC26130 GSK8612 Featured GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
DC10471 GSK-872 Featured GSK-872 is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor.
DC7812 GSK923295 Featured GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183.
DC9907 GSK9311 Featured GSK9311 is a potent and highly selective inhibitor of the BRPF bromodomain (BRPDF1 pIC50 = 6.0; BRPDF2 pIC50 = 4.3).
DC10061 PI4KA inhibitor-A1 Featured GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM.
DC10064 GSK-F1 Featured GSK-F1 is a potent inhibitor of PI4KA.
DC7858 GSK-J1 Featured GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro).
DC7857 GSK-LSD1 Featured GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1).
DC23890 GSM-1 GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
DC23886 GSM-2 GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.
DC20399 GSTO1 inhibitor C1-27 GSTO1 inhibitor C1-27 is a potent, selective, covalent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM.
DC20112 GT 949 Featured GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM.
DC21403 GTC 365 GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.
DC21404 GTC 365 hydrochloride GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.

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