DC10936 |
GSK3179106
Featured
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GSK3179106 (GSK-3179106, GSK 3179106) is a potent, selective, first-in-class and gut-restricted with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively. |
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DC10647 |
EPZ015938(pemrametostat)
Featured
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GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor. |
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DC7143 |
GSK-343
Featured
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GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. |
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DC8505 |
GSK369796
Featured
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GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain |
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DC1035 |
GSK3787
Featured
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GSK3787 is as a potent and selective antagonist of PPARδ with pIC50 of 6.6. |
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DC8648 |
GSK4112
Featured
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GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. |
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DC7144 |
GSK429286A
Featured
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GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
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DC22306 |
cGAS inhibitor 467
Featured
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GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1). GSK467 exploits unique binding modes. |
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DC8589 |
PAD4 inhibitor GSK484
Featured
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GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. |
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DC8044 |
GSK503
Featured
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GSK503 is a specific EZH2 methyltransferase inhibitor. |
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DC12513 |
RIP1 inhibitor GSK547
Featured
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GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo. |
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DC9733 |
GSK583
Featured
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GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM). |
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DC10391 |
EBI2 inhibitor GS682753A |
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
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DC9831 |
GSK6853
Featured
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GSK6853 is a potent, soluble, cell active, and highly selective inhibitor of the BRPF1 bromodomain |
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DC2070 |
GSK690693
Featured
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GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
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DC8373 |
GSK8573
Featured
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GSK-8573 is the inactive control of GSK-2801. |
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DC26130 |
GSK8612
Featured
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. |
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DC10471 |
GSK-872
Featured
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GSK-872 is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor. |
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DC7812 |
GSK923295
Featured
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GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. |
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DC9907 |
GSK9311
Featured
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GSK9311 is a potent and highly selective inhibitor of the BRPF bromodomain (BRPDF1 pIC50 = 6.0; BRPDF2 pIC50 = 4.3). |
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DC10061 |
PI4KA inhibitor-A1
Featured
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GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM. |
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DC10064 |
GSK-F1
Featured
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GSK-F1 is a potent inhibitor of PI4KA. |
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DC7858 |
GSK-J1
Featured
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GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). |
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DC7857 |
GSK-LSD1
Featured
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GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). |
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DC23890 |
GSM-1 |
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay. |
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DC23886 |
GSM-2 |
GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels. |
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DC20399 |
GSTO1 inhibitor C1-27 |
GSTO1 inhibitor C1-27 is a potent, selective, covalent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM. |
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DC20112 |
GT 949
Featured
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GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM. |
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DC21403 |
GTC 365 |
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters. |
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DC21404 |
GTC 365 hydrochloride |
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters. |
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