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Cat. No. Product Name Field of Application Chemical Structure
DC8303 GTS 21 2HCl(DMXBA) Featured GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations.
DCAPI1387 Guaifenesin(Guaiphenesin) Guaifenesin(Guaiphenesin)
DC21825 Guanabenz Featured Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-P
DC10233 Guanfacine Hydrochloride Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
DC12076 Guanidinosuccinic acid Guanidinosuccinic acid is a nitrogenous metabolite isolated in excess from serum and urine.
DC9819 Guanoclor Featured Guanoclor is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
DC23297 GUT-70 GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis.
DC23117 GV-58 GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM).
DC9458 GW-1100 GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
DC21102 GW 275175X GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation.
DC7566 GW-4064 Featured GW 4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
DC7145 GW441756 Featured GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.
DC8810 GW-5074 Featured GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM); displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms.
DC8266 GW-627368X Featured GW 627368X is a selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays).
DC2078 GW-7647 Featured GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ.
DC23402 GW 841819X GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia..
DC9904 GW0742 Featured GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
DC7149 GW1929 Featured GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively.
DC1018 GW-2580 (GW2580) Featured GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM.
DC23142 GW274150 Featured GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.Target: iNOSin vivo: GW274150 demonstrates a narrow neuroprotective therapeutic window against the toxic actions of 6-OHDA. GW274150 administration leads to a dose-dependent decrease in the number of iNOS-positive cells in the SNc of the 6-OHDA-lesioned animals. The iNOS inhibitor GW274150 fails to produce long-term neuroprotection after its withdrawal in the 6-OHDA-lesioned rat. [1]
DC8193 GW311616A GW311616A is a potent, intracellular human neutrophil elastase (HNE, α-1-proteinase) inhibitor.
DC7837 GW-3965 hydrochloride Featured GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.
DC12644 GW406108X GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.
DC7662 GW4869 Featured GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).
DC4233 GW501516 Featured GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes.
DC7980 GW-6604 Featured GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity.
DC23530 GW-766994 R-form GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
DC23531 GW-766994 GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
DC7146 GW788388 Featured GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
DC10503 GW806742X Featured GW806742X is a novel VEGFR inhibitor.

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