DC8303 |
GTS 21 2HCl(DMXBA)
Featured
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GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. |
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DCAPI1387 |
Guaifenesin(Guaiphenesin) |
Guaifenesin(Guaiphenesin) |
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DC21825 |
Guanabenz
Featured
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Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-P |
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DC10233 |
Guanfacine Hydrochloride |
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. |
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DC12076 |
Guanidinosuccinic acid |
Guanidinosuccinic acid is a nitrogenous metabolite isolated in excess from serum and urine. |
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DC9819 |
Guanoclor
Featured
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Guanoclor is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. |
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DC23297 |
GUT-70 |
GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis. |
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DC23117 |
GV-58 |
GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM). |
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DC9458 |
GW-1100 |
GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
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DC21102 |
GW 275175X |
GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation. |
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DC7566 |
GW-4064
Featured
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GW 4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). |
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DC7145 |
GW441756
Featured
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GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. |
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DC8810 |
GW-5074
Featured
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GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM); displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. |
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DC8266 |
GW-627368X
Featured
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GW 627368X is a selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). |
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DC2078 |
GW-7647
Featured
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GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. |
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DC23402 |
GW 841819X |
GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia.. |
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DC9904 |
GW0742
Featured
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GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively. |
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DC7149 |
GW1929
Featured
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GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively. |
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DC1018 |
GW-2580 (GW2580)
Featured
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GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM. |
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DC23142 |
GW274150
Featured
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GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.Target: iNOSin vivo: GW274150 demonstrates a narrow neuroprotective therapeutic window against the toxic actions of 6-OHDA. GW274150 administration leads to a dose-dependent decrease in the number of iNOS-positive cells in the SNc of the 6-OHDA-lesioned animals. The iNOS inhibitor GW274150 fails to produce long-term neuroprotection after its withdrawal in the 6-OHDA-lesioned rat. [1] |
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DC8193 |
GW311616A |
GW311616A is a potent, intracellular human neutrophil elastase (HNE, α-1-proteinase) inhibitor. |
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DC7837 |
GW-3965 hydrochloride
Featured
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GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
|
DC12644 |
GW406108X |
GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays. |
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DC7662 |
GW4869
Featured
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GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). |
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DC4233 |
GW501516
Featured
|
GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. |
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DC7980 |
GW-6604
Featured
|
GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. |
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DC23530 |
GW-766994 R-form |
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays. |
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DC23531 |
GW-766994 |
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays. |
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DC7146 |
GW788388
Featured
|
GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor. |
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DC10503 |
GW806742X
Featured
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GW806742X is a novel VEGFR inhibitor. |
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