DC8609 |
GW843682X
Featured
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GW843682X is a cell-permeable thiophene-benzimidazole compound and reversible PLK inhibitor |
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DC22653 |
GW-8510
Featured
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GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM. |
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DC1086 |
GW-9508
Featured
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GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32. |
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DC2079 |
GW-9662
Featured
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GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. |
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DC11993 |
GWJ-A-23 |
GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. |
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DC26080 |
GX-674
Featured
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GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM. |
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DC23613 |
GX-936 |
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM. |
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DC5061 |
GYKI 52466 dihydrochloride |
GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
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DC10668 |
GYY4137 morpholine salt
Featured
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GYY 4137 is a Water-soluble, slow-releasing hydrogen sulfide donor. |
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DC22106 |
GZ389988 |
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis. |
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DC7147 |
GZD824
Featured
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GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. |
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DC20118 |
GZD856
Featured
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GZD856 is a novel and orally bioavailable PDGFRα/β inhibitor with IC50s of 68.6 and 136.6 nM, respectively. Anti-lung cancer activities. Also a Bcr-AblT315I inhibitor with IC50s of 19.9 and 15.4 nM for Bcr-Abl and T315I mutant. |
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DC7835 |
H-89 2HCl
Featured
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H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. |
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DC10876 |
H-151
Featured
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H-151(H151) is a novel STING (stimulator of interferon genes) antagonist. |
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DC11010 |
H3B-5942 |
H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA), demonstrates potent ERαantagonist activity in vitro and in vivo. |
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DC10033 |
H3B-6527
Featured
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H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. |
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DC21105 |
H3B-8800
Featured
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H3B8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM),demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells.. H3B-8800 potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. |
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DC12266 |
H4 Receptor antagonist 1 |
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. |
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DC20106 |
H4R antagonist 1 |
H4R antagonist 1 |
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DC8563 |
HA130
Featured
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HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. |
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DC1066 |
HA14-1
Featured
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HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
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DC9795 |
HA-15
Featured
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HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
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DC9567 |
Halcinonide |
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions. |
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DC9749 |
Halofuginone |
Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
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DCAPI1229 |
Haloperidol (Haldol) |
Haloperidol (Haldol) |
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DC10935 |
HAMI3379 |
HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively. |
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DC10741 |
HAMNO (NSC111847)
Featured
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HAMNO is a novel protein interaction inhibitor of replication protein A (RPA). |
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DC21106 |
HAP-12 |
HAP-12 is a small molecule HBV capsid assembly effector that inhibits HBV DNA replication with EC50 of 0.5 uM.. |
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DC23253 |
HAR-171 |
HAR-171 is a small molecule gp120-CD40 blocker that acts as a highly potent HIV entry inhibitor with IC50 of 0.43 uM against YTA48P virus with no significant cytotoxicity (CC50>120 uM).. |
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DC12224 |
H-Arg-4MβNA |
H-Arg-4MβNA is a substrate for cathepsin H, used for the detection of enzyme activity in gel electrophoresis. |
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