| DC21116 |
HJC0197
Featured
|
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP. |
|
| DC21118 |
HJC 0726 |
HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM. |
|
| DC10626 |
HJC0152 |
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. |
|
| DC21117 |
HJC-0338 |
HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2. |
|
| DC7638 |
HJC-0350
Featured
|
HJC-0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells. |
|
| DC11366 |
HKI 357 |
HKI 357 is an irreversible dual inhibitor of the EGF receptor tyrosine kinases EGFR and HER2 (IC50s = 34 and 33 nM, respectively). |
|
| DC21119 |
HL001 |
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
|
| DC9678 |
HLCL-61 hydrochloride
Featured
|
HLCL-61 is a first-in-class small-molecule inhibitor of PRMT5 for treatment of acute myeloid leukemia. |
|
| DC21977 |
HlyU inhibitor CM14 |
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30. |
|
| DC10414 |
HM30181(Encequidar)
Featured
|
HM30181 is a potent and selective inhibitor of P-glycoprotein. |
|
| DC12074 |
HM30181 mesylate
Featured
|
HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor. |
|
| DC8819 |
Olmutinib (HM61713; BI-1482694)
Featured
|
HM-61713 (BI-1482694) is an orally available small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. |
|
| DC10517 |
HMN-154
Featured
|
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively. |
|
| DC9957 |
HMN-176
Featured
|
HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization. |
|
| DC8768 |
HMN-214
Featured
|
HMN-214(IVX214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM. |
|
| DC20407 |
HMPC |
HMPC is a novel bacteriostatic agent that shows bacteriostatic activity against S. aureus (MIC=4 μg/ml) and rescues Caenorhabditis elegans from S. aureus infection. |
|
| DC22107 |
HMS-101 |
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
|
| DC6314 |
Icatibant acetate
Featured
|
HOE-140 (Icatibant) is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM). |
|
| DC9415 |
Hoechst 33342 (trihydrochloride) |
Hoechst 33342 3Hcl(HOE 33342 3Hcl) is an AT-specific DNA minor groove ligand used fluorochrome for visualizing cellular DNA. |
|
| DC9418 |
Hoechst 33258 analog |
Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA.
|
|
| DC22129 |
HOIPIN-1(JTP-0819958;HOIP inhibitor-1)
Featured
|
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the N |
|
| DC22108 |
HOIPIN-8
Featured
|
HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pa |
|
| DC9650 |
Homoharringtonine
Featured
|
Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree. |
|
| DC10177 |
Homoplantaginin |
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties. |
|
| DC5908 |
Honokiol
Featured
|
Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines. |
|
| DC12154 |
Hosenkoside A |
Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
|
| DC12148 |
Hosenkoside B |
Hosenkoside B is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
|
| DC12152 |
Hosenkoside F ((+)-Hosenkoside F) |
Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
|
| DC12153 |
Hosenkoside K |
Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
|
| DC12149 |
Hosenkoside M ((+)-Hosenkoside M) |
Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
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