| DC23634 |
HBT1 |
HBT1 is a novel potent AMPA receptor potentiator with lower agonistic effect compared with LY451395 and OXP1.. |
|
| DC20917 |
HBV Capsid inhibitor 3711 |
HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
|
| DC10354 |
HBX 19818
Featured
|
HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
|
| DC23783 |
HBX 28258 |
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
|
| DC8207 |
HBX41108
Featured
|
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). |
|
| DC5200 |
HC-030031
Featured
|
HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
|
| DC12197 |
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) |
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM). |
|
| DC11416 |
HC-067047
Featured
|
HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). |
|
| DC21108 |
HC-070 |
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
|
| DC12620 |
hClpP activator D9
Featured
|
hClpP activator D9 is a potent and species-selective activator of human ClpP (hClpP, human Caseinolytic protease P) by mimicking the natural chaperone ClpX.. |
|
| DC8828 |
HDAC inhibitor IV
Featured
|
HDAC inhibitor IV is a cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. |
|
| DC10932 |
HDAC6 degrader 9c |
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
|
| DC20401 |
HDAC6-AR-IN-10 |
HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM). |
|
| DC11594 |
HDAC8-IN-20a |
HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM. |
|
| DC10596 |
Lavendustin C (HDBA)
Featured
|
HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM. |
|
| DC10613 |
NVP-HDM201(Siremadlin )
Featured
|
HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. |
|
| DC21113 |
HEC72702 |
HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM. |
|
| DC21114 |
HEC-73543 |
HEC-73543 is a novel potent, selective, orally bioavailable FLT3 inhibitor for the treatment of refractory acute myeloid leukemia (AML). |
|
| DC9921 |
Hederacoside C
Featured
|
Hederacoside C is a principal bioactive pharmaceutical ingredient of Hedera helix leaf that can treat respiratory disorders, because of its expectorant, bronchodilator, antibacterial, and bronchospasmolytic effects. |
|
| DC9823 |
Hederagenin
Featured
|
Hederagenin a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases. |
|
| DC20402 |
Hedgehog-IN-7d |
Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.. |
|
| DC21414 |
Helenalin |
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
|
| DC21109 |
Hemicholinium-3 |
Hemicholinium-3 (HC-3) is a competitive, small molecule inhibitor of choline kinase (ChoK) with ex vivo IC50 of 500 uM, also bolcks the sodium and chloride-dependent transport system and affects choline acetyltransferase. |
|
| DC24152 |
Hemin |
Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type. |
|
| DC21115 |
TD-1
Featured
|
Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. |
|
| DC12294 |
Heparin lithium salt
Featured
|
Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). |
|
| DC10422 |
Heptamethine cyanine dye-1 |
Heptamethine cyanine dye-1 is a near-infrared cyanine dye for fluorescence imaging in biological systems. |
|
| DC20403 |
HER2-IN-2 |
HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases. |
|
| DC20404 |
HER2-IN-3 |
HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2. |
|
| DC23730 |
Herboxidiene |
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
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