| DC21130 |
I-191
Featured
|
I-191 is a novel potent, selective protease-activated receptor 2 (PAR2) antagonist with pIC50 of 7.2 in cell-based assays. |
|
| DC8601 |
IAA-94 |
IAA-94 is an indanyloxyacetic acid blocker of epithelial chloride channels. |
|
| DC11262 |
IACS-010759
Featured
|
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
|
| DC12105 |
IACS-10759 Hydrochloride |
IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
|
| DC21131 |
IACS-4619 |
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM. |
|
| DC21132 |
IACS-4759 |
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM. |
|
| DC23352 |
IACS-7e |
IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).. |
|
| DC23361 |
IACS-9571 |
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
|
| DC23546 |
IAXO-102 |
IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development. |
|
| DC10174 |
Iberdomide
Featured
|
Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay. |
|
| DC10361 |
Iberin
Featured
|
Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. |
|
| DC5183 |
I-BET151
Featured
|
I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM, respectively. |
|
| DC21905 |
IBET151-VHL-PROTAC |
IBET151-VHL-PROTAC is a novel PROTAC.. |
|
| DC10007 |
Ibiglustat(Genz-682452）
Featured
|
Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
|
| DC12341 |
Ibiglustat succinate (Venglustat (succinate); GZ/SAR402671 (succinate))
Featured
|
Ibiglustat (succinate) is a selective inhibitor of glucosylceramide synthase. |
|
| DC7635 |
IB-MECA
Featured
|
IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). |
|
| DC7676 |
IBMX(NSC165960; SC2964)
Featured
|
IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist. |
|
| DC21134 |
IBR2 |
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM. |
|
| DC9658 |
I-BRD9
Featured
|
I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. |
|
| DC22112 |
IBS003031 |
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
|
| DC8983 |
Ibudilast
Featured
|
Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma,ibudilast (MN-166) is tested to treat acute respiratory distress syndrome (ARDS) associated with Covid-19. |
|
| DC8573 |
Ibufenac |
Ibufenac is an analog of the NSAID ibuprofen that inhibits COX-1 and -2 activity with IC50 values of 17.4 and 13.1 µM, respectively. |
|
| DC20411 |
Ibulocydine |
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
|
| DC8965 |
Ibuprofen |
Ibuprofen (Motrin) is an anti-inflammatory inhibitor targeting COX-1 and COX-2, of which is used for pain relief, fever reduction and for reducing swelling. |
|
| DC7020 |
Ibutamoren mesylate
Featured
|
Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. |
|
| DC9163 |
Ibutilide fumarate |
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. |
|
| DC21135 |
IC 86621
Featured
|
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM). |
|
| DC21136 |
IC 87361 |
IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β. |
|
| DC9730 |
IC-261(SU-5607)
Featured
|
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM. |
|
| DC7156 |
IC-87114
Featured
|
IC-87114 was the first isoform-selective PI3K inhibitor. p110δ(IC50 = 0.13 μM) vs. p110α(IC50 = 200 μM), p110β(IC50 = 16 μM) and p110γ(IC50 = 61 μM). |
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